Review on recent advancements in understanding acetylsalicylic acid-induced gastrointestinal injury: mechanisms, medication, and dosage refinement

被引：0

作者：

Zhou, Jiahui ^{[1
,2
,3
,4
]}

Li, Na ^{[1
,2
,3
,4
]}

Li, Xinzhong ^{[1
,2
,3
,4
]}

Ye, Jingxue ^{[1
,2
,3
,4
]}

Wang, Min ^{[1
,2
,3
,4
]}

Sun, Guibo ^{[1
,2
,3
,4
]}

机构：

[1] Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Beijing, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China

[3] NMPA Key Lab Res & Evaluat Pharmacovigilance, Beijing, Peoples R China

[4] Chinese Acad Med Sci, Key Lab New Drug Discovery Based Class Chinese Med, Beijing, Peoples R China

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2024年

关键词：

Acetylsalicylic acid; Gastrointestinal injury; Mechanism; Formulation; LOW-DOSE ASPIRIN; GASTRIC-MUCOSAL DAMAGE; PROTON-PUMP INHIBITORS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; COORDINATED-DELIVERY TABLET; SMALL-BOWEL INJURIES; OXIDATIVE STRESS; DOUBLE-BLIND; LYOPHILIZED ASPIRIN; COMBINING ASPIRIN;

D O I：

10.1007/s00210-024-03521-w

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acetylsalicylic acid (ASA) is a clinical drug with multiple effects, including prevention of cardiovascular adverse events and anti-cancer effects. However, gastrointestinal side effects, such as gastrointestinal ulcers and bleeding, limit the use of ASA and reduce patient compliance. Various studies have investigated the mechanisms of ASA-induced gastrointestinal injury, and many medicines have been reported to be effective in preventing and treating the adverse gastrointestinal effects of ASA. New formulations of ASA have demonstrated milder gastrointestinal injury than ASA alone. In this article, we summarized the mechanisms of ASA-induced gastrointestinal injury, drugs that resist gastrointestinal side effects of ASA, and progress in research on formulation improvement of ASA to help resolve the clinical dilemma of ASA usage.

引用

页码：3297 / 3320

页数：24

共 180 条

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