A New Benzofuran from the Roots of Eupatorium chinense L. and Its α-Glucosidase and PTP1B Inhibitory Activities

被引：0

作者：

Qin, Qiangsu ^{[1
]}

Yang, Huishu ^{[1
]}

Qin, Yifa ^{[1
]}

Bai, Yifan ^{[1
]}

Tang, Renqin ^{[1
]}

Yan, Ting ^{[1
]}

Liu, Zhaoxia ^{[1
]}

Liu, Chengxiong ^{[1
]}

Yu, Xiaoqin ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Key Lab Funct Yeast China Natl Light Ind, Yichang, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2024年 / 18卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Eupatorium chinense L; chemical constituents; antidiabetic activity; alpha-glucosidase; protein tyrosine phosphatase 1B;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new benzofuran, named eupbenzofuran A (1), along with four known compounds, 10,11-dihydroxy10,11-dihydroeuparin (2), 5-[1'-hydroxyethyl]-2-1 '-hydroxyisoprolyl]-benzofuran (3), 3 alpha,6-dihydroxytremetone (4), odoratin (5) were isolated from the roots of Eupatorium chinense L. The structure of compounds were identified by NMR, MS, CD and other spectroscopic methods and comparisons with relevant literature data. Compound 1 had favorable dual inhibitory activities against alpha-glucosidase and protein tyrosine phosphatase 1B (PTP1B). However, compounds 2- 5 had no significant inhibitory activities effects on alpha-glucosidase and PTP1B (IC50>50 mu g/mL). Molecular docking technique was used to calculate the interaction of compound 1 with alpha-glucosidase and PTP1B, respectively, and the calculated results showed that compound 1 had both strong binding to and PTP1B.

引用

页码：693 / 698

页数：6

共 16 条

[1]

Anh L. T. T., 2024, Rec. Nat. Prod., V18, P363

[2] NATURALLY-OCCURRING TERPENE DERIVATIVES .260. NEW MELAMPOLIDES FROM SMALLANTHUS-FRUTICOSIS [J].