The mitochondria-gut microbiota crosstalk - A novel frontier in cardiovascular diseases

被引:0
作者
Kulkarni, Hrushikesh [1 ]
Gaikwad, Anil Bhanudas [1 ]
机构
[1] Birla Inst Technol & Sci, Dept Pharm, Pilani Campus, Pilani 333031, Rajasthan, India
关键词
Gut microbiota; Mitochondria; Cardiovascular disease; Novel biomarkers; Therapy; BLOOD-PRESSURE; DYSFUNCTION; RECEPTOR; ACTIVATION;
D O I
10.1016/j.ejphar.2025.177562
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cardiovascular diseases (CVDs), including hypertension, atherosclerosis, and cardiomyopathy among others, remain the leading cause of global morbidity and mortality. Despite advances in treatment, the complex pathophysiology of CVDs necessitates innovative approaches to improve patient outcomes. Recent research has uncovered a dynamic interplay between mitochondria and gut microbiota, fundamentally altering our understanding of cardiovascular health. However, while existing studies have primarily focused on individual components of this axis, this review examines the bidirectional communication between these biological systems and their collective impact on cardiovascular health. Mitochondria, serving as cellular powerhouses, are crucial for maintaining cardiovascular homeostasis through oxidative phosphorylation (OXPHOS), calcium regulation, and redox balance. Simultaneously, the gut microbiota influences cardiovascular function through metabolite production, barrier integrity maintenance, and immune system modulation. The mitochondria-gut microbiota axis operates through various molecular mechanisms, including microbial metabolites such as trimethylamine Noxide (TMAO), short-chain fatty acids (SCFA), and secondary bile acids, which directly influence mitochondrial function. Conversely, mitochondrial stress signals and damage-associated molecular patterns (DAMPs) affect gut microbial communities and barrier function. Key signalling pathways, including AMP-activated protein kinase (AMPK), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), and the silent information regulator 1-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (SIRT1-PGC-1 alpha) axis, integrate these interactions, highlighting their role in CVD pathogenesis. Understanding these interactions has revealed promising therapeutic targets, suggesting new therapies aimed at both mitochondrial function and gut microbiota composition. Thus, this review provides a comprehensive framework for leveraging the mitochondria-gut microbiota axis in providing newer therapeutics for CVDs by targeting the AMPK/SIRT-1/PGC1 alpha/NF-kappa B signalling.
引用
收藏
页数:9
相关论文
共 98 条
[1]  
Abdi M, 2022, IRAN J BASIC MED SCI, V25, P934, DOI [10.22038/IJBMS.2022.63860.14073, 10.22038/ijbms.2022.63860.14073]
[2]   Human gut microbiota in health and disease: Unveiling the relationship [J].
Afzaal, Muhammad ;
Saeed, Farhan ;
Shah, Yasir Abbas ;
Hussain, Muzzamal ;
Rabail, Roshina ;
Socol, Claudia Terezia ;
Hassoun, Abdo ;
Pateiro, Mirian ;
Lorenzo, Jose M. ;
Rusu, Alexandru Vasile ;
Aadil, Rana Muhammad .
FRONTIERS IN MICROBIOLOGY, 2022, 13
[3]   A randomized trial to determine the impact of a digestion resistant starch composition on the gut microbiome in older and mid-age adults [J].
Alfa, Michelle J. ;
Strang, David ;
Tappia, Paramjit S. ;
Graham, Morag ;
Van Domselaar, Gary ;
Forbes, Jessica D. ;
Laminman, Vanessa ;
Olson, Nancy ;
DeGagne, Pat ;
Bray, David ;
Murray, Brenda-Lee ;
Dufault, Brenden ;
Lix, Lisa M. .
CLINICAL NUTRITION, 2018, 37 (03) :797-807
[4]   The BES upgrade [J].
Bai, JZ ;
Bao, HC ;
Blum, I ;
Chai, ZW ;
Chen, GP ;
Chen, HF ;
Chen, J ;
Chen, JC ;
Chen, Y ;
Chen, YB ;
Chen, YQ ;
Cheng, BS ;
Chu, XM ;
Cui, XZ ;
Ding, HL ;
Ding, WY ;
Dong, LY ;
Du, YY ;
Du, ZZ ;
Dunwoodie, W ;
Fang, J ;
Fang, WZ ;
Gao, CS ;
Gao, ML ;
Gao, SQ ;
Gratton, P ;
Gu, JH ;
Gu, SD ;
Gu, WX ;
Guo, YN ;
Han, HG ;
Han, SW ;
Harris, FA ;
Han, Y ;
He, J ;
He, M ;
Heng, YK ;
Hitlin, DG ;
Hu, GY ;
Hu, HB ;
Hu, HM ;
Hu, JL ;
Hu, QH ;
Hu, T ;
Hu, XQ ;
Huang, GS ;
Huang, JD ;
Huang, YZ ;
Izen, JM ;
Jiang, CH .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2001, 458 (03) :627-637
[5]   Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction [J].
Boini, Krishna M. ;
Hussain, Tahir ;
Li, Pin-Lan ;
Koka, Saisudha .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 44 (01) :152-162
[6]   Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles [J].
Bonora, Massimo ;
Wieckowski, Mariusz R. ;
Sinclair, David A. ;
Kroemer, Guido ;
Pinton, Paolo ;
Galluzzi, Lorenzo .
NATURE REVIEWS CARDIOLOGY, 2019, 16 (01) :33-55
[7]   Microbial modulation of cardiovascular disease [J].
Brown, J. Mark ;
Hazen, Stanley L. .
NATURE REVIEWS MICROBIOLOGY, 2018, 16 (03) :171-181
[8]  
Cai G, 2023, INT J RADIAT ONCOL, V117, pS119, DOI 10.1016/j.ijrobp.2023.06.455
[9]   Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs [J].
Castellani, Christina A. ;
Longchamps, Ryan J. ;
Sumpter, Jason A. ;
Newcomb, Charles E. ;
Lane, John A. ;
Grove, Megan L. ;
Bressler, Jan ;
Brody, Jennifer A. ;
Floyd, James S. ;
Bartz, Traci M. ;
Taylor, Kent D. ;
Wang, Penglong ;
Tin, Adrienne ;
Coresh, Josef ;
Pankow, James S. ;
Fornage, Myriam ;
Guallar, Eliseo ;
O'Rourke, Brian ;
Pankratz, Nathan ;
Liu, Chunyu ;
Levy, Daniel ;
Sotoodehnia, Nona ;
Boerwinkle, Eric ;
Arking, Dan E. .
GENOME MEDICINE, 2020, 12 (01)
[10]   Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway [J].
Chen, Ming-liang ;
Zhu, Xiao-hui ;
Ran, Li ;
Lang, He-dong ;
Yi, Long ;
Mi, Man-tian .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (09)