Behcet's disease-related panuveitis following COVID-19 vaccination: A case report

被引：0

作者：

Lin, Rou-Ting ^{[1
,2
]}

Liu, Pei-Kang ^{[3
,4
]}

Chang, Chia-Wei ^{[2
]}

Cheng, Kai-Chun ^{[3
,4
,5
]}

Chen, Kuo-Jen ^{[5
]}

Chang, Yo-Chen ^{[3
,4
]}

机构：

[1] Chung Shan Med Univ, Coll Med, Sch Med, Taichung 40201, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Clin Educ & Training, Kaohsiung 80756, Taiwan

[3] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Ophthalmol, 100 Zihyou 1st Rd, Kaohsiung 80737, Taiwan

[4] Kaohsiung Med Univ Hosp, Dept Ophthalmol, Kaohsiung 80756, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Ophthalmol, Kaohsiung 81201, Taiwan

来源：

WORLD JOURNAL OF RADIOLOGY | 2024年 / 16卷 / 09期

关键词：

Behcet's disease; mRNA COVID-19 vaccine; Ocular inflammation; Panuveitis; Case report; ETIOLOGY; UVEITIS;

D O I：

10.4329/wjr.v16.i9.460

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

BACKGROUND Behcet's disease (BD) is an inflammatory disorder known for various symptoms, including oral and genital ulcers and ocular inflammation. Panuveitis, a severe eye condition, is rare as the first sign of BD. CASE SUMMARY We present an unusual case of a 30-year-old man who developed panuveitis after receiving the mRNA-based coronavirus disease 2019 (COVID-19) vaccine (Moderna). Laboratory tests ruled out infections, but he had a positive HLA-B51 result and a history of genital ulcer and oral ulcers, leading to a BD diagnosis. Treatment with corticosteroids improved his condition. Interestingly, he had another episode of panuveitis after the second mRNA vaccine dose, which also responded to corticosteroids. CONCLUSION This case highlights the rare onset of BD following mRNA COVID-19 vaccination, suggesting a potential link between these vaccines and BD's eye symptoms, emphasizing the importance of quick treatment in similar cases.

引用

页数：7

共 16 条

[1] The COVID-19 Pandemic from an Ophthalmologist's Perspective [J].

Bacherini, Daniela ;

Biagini, Ilaria ;

Lenzetti, Chiara ;

Virgili, Gianni ;

Rizzo, Stanislao ;

Giansanti, Fabrizio .

TRENDS IN MOLECULAR MEDICINE, 2020, 26 (06) :529-531

[2] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[3] Prognostic factors of ocular involvement in Behcet's disease [J].

Belkhadir, K. ;

Boutimzine, N. ;

Laghmari, M. ;

Amazouzi ;

Tachfouti, S. ;

Cherkaoui, O. .

JOURNAL FRANCAIS D OPHTALMOLOGIE, 2019, 42 (06) :612-617

[4] Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2 [J].

Blumenthal, Kimberly G. ;

Freeman, Esther E. ;

Saff, Rebecca R. ;

Robinson, Lacey B. ;

Wolfson, Anna R. ;

Foreman, Ruth K. ;

Hashimoto, Dean ;

Banerji, Aleena ;

Li, Lily ;

Anvari, Sara ;

Shenoy, Erica S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (13) :1273-1277

[5] Chronic severe uveitis - Etiology and visual outcome in 927 patients from a single center [J].

Bodaghi, B ;

Cassoux, N ;

Wechsler, B ;

Hannouche, D ;

Fardeau, C ;

Papo, T ;

Huong, DLT ;

Piette, JC ;

LeHoang, P .

MEDICINE, 2001, 80 (04) :263-270

[6] SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness [J].

Corbett, Kizzmekia S. ;

Edwards, Darin K. ;

Leist, Sarah R. ;

Abiona, Olubukola M. ;

Boyoglu-Barnum, Seyhan ;

Gillespie, Rebecca A. ;

Himansu, Sunny ;

Schafer, Alexandra ;

Ziwawo, Cynthia T. ;

DiPiazza, Anthony T. ;

Dinnon, Kenneth H. ;

Elbashir, Sayda M. ;

Shaw, Christine A. ;

Woods, Angela ;

Fritch, Ethan J. ;

Martinez, David R. ;

Bock, Kevin W. ;

Minai, Mahnaz ;

Nagata, Bianca M. ;

Hutchinson, Geoffrey B. ;

Wu, Kai ;

Henry, Carole ;

Bahl, Kapil ;

Garcia-Dominguez, Dario ;

Ma, LingZhi ;

Renzi, Isabella ;

Kong, Wing-Pui ;

Schmidt, Stephen D. ;

Wang, Lingshu ;

Zhang, Yi ;

Phung, Emily ;

Chang, Lauren A. ;

Loomis, Rebecca J. ;

Altaras, Nedim Emil ;

Narayanan, Elisabeth ;

Metkar, Mihir ;

Presnyak, Vlad ;

Liu, Cuiping ;

Louder, Mark K. ;

Shi, Wei ;

Leung, Kwanyee ;

Yang, Eun Sung ;

West, Ande ;

Gully, Kendra L. ;

Stevens, Laura J. ;

Gully, Kendra L. ;

Wang, Nianshuang ;

Wrapp, Daniel ;

Doria-Rose, Nicole A. ;

Stewart-Jones, Guillaume .

NATURE, 2020, 586 (7830) :567-+

[7] Behcet's disease: epidemiology, clinical manifestations, and diagnosis [J].

Davatchi, Fereydoun ;

Chams-Davatchi, Cheyda ;

Shams, Hormoz ;

Shahram, Farhad ;

Nadji, Abdolhadi ;

Akhlaghi, Massoomeh ;

Faezi, Tahreh ;

Ghodsi, Zahra ;

Abdollahi, Bahar Sadeghi ;

Ashofteh, Farimah ;

Mohtasham, Negin ;

Kavosi, Hoda ;

Masoumi, Mariam .

EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2017, 13 (01) :57-65

[8] HLA-B51/B5 and the Risk of Behcet's Disease: A Systematic Review and Meta-Analysis of Case-Control Genetic Association Studies [J].

de Menthon, Mathilde ;

LaValley, Michael P. ;

Maldini, Carla ;

Guillevin, Loic ;

Mahr, Alfred .

ARTHRITIS CARE & RESEARCH, 2009, 61 (10) :1287-1296

[9] Behet's disease: infectious aetiology, new autoantigens, and HLA-B51 [J].

Direskeneli, H .

ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (11) :996-1002

[10] Current concepts in the etiology and treatment of Behcet disease [J].

Evereklioglu, C .

SURVEY OF OPHTHALMOLOGY, 2005, 50 (04) :297-350

← 1 2 →