Targeting protein modification: a new direction for immunotherapy of pancreatic cancer

被引：1
作者：
Ge, Xinyu [1 ]
Zhang, Ke [2 ]
Zhu, Jie [1 ]
Chen, Yuan [1 ]
Wang, Zhengwang [1 ]
Wang, Peng [1 ]
Xu, Peng [1 ]
Yao, Jie [1 ]
机构：
[1] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Yangzhou 225000, Jiangsu, Peoples R China
[2] Dalian Med Univ, Yangzhou Sch Clin Med, Yangzhou 225000, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2025年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Post-translational modifications; Immunotherapy; Targeted therapy; Immune escape; Pancreatic cancer; PD-L1; EXPRESSION; AUGMENTS IMMUNOTHERAPY; ACTIVATION; INHIBITION; PHOSPHORYLATION; GLYCOSYLATION; PATHWAY; GROWTH; CELLS; SUMO;
D O I：
10.7150/ijbs.101861
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processes, including tumor transformation, cancer progression, and metastasis in pancreatic cancer. Additionally, advancements in tumor immunotherapy indicate that PTMs are essential in immune cell activation, transport, and energy metabolism. This study aimed to investigate the effects of different PTMs on immunotherapy for pancreatic cancer, providing new perspectives and suggesting directions for future research.
引用
收藏
页码：63 / 74
页数：12
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共 167 条
  • [21] Antibody Induction Directed against the Tumor-Associated MUC4 Glycoprotein
    Cai, Hui
    Palitzsch, Bjoern
    Hartmann, Sebastian
    Stergiou, Natascha
    Kunz, Horst
    Schmitt, Edgar
    Westerlind, Ulrika
    [J]. CHEMBIOCHEM, 2015, 16 (06) : 959 - 967
  • [22] Human natural killer cells
    Caligiuri, Michael A.
    [J]. BLOOD, 2008, 112 (03) : 461 - 469
  • [23] Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts
    Celen, Arda B.
    Sahin, Umut
    [J]. FEBS JOURNAL, 2020, 287 (15) : 3110 - 3140
  • [24] Mechanisms Controlling PD-L1 Expression in Cancer
    Cha, Jong-Ho
    Chan, Li-Chuan
    Li, Chia-Wei
    Hsu, Jennifer L.
    Hung, Mien-Chie
    [J]. MOLECULAR CELL, 2019, 76 (03) : 359 - 370
  • [25] SUMO: FROM BENCH TO BEDSIDE
    Chang, Hui-Ming
    Yeh, Edward T. H.
    [J]. PHYSIOLOGICAL REVIEWS, 2020, 100 (04) : 1599 - 1619
  • [26] Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into CheckpointResponsive Tumors by Reprogramming Tumor-Infiltrating MDSCs
    Christmas, Brian J.
    Rafie, Christine I.
    Hopkins, Alexander C.
    Scott, Blake A.
    Ma, Hayley S.
    Cruz, Kayla A.
    Woolman, Skylar
    Armstrong, Todd D.
    Connolly, Roisin M.
    Azad, Nilo A.
    Jaffee, Elizabeth M.
    Torres, Evanthia T. Roussos
    [J]. CANCER IMMUNOLOGY RESEARCH, 2018, 6 (12) : 1561 - 1577
  • [27] STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis
    Corcoran, Ryan B.
    Contino, Gianmarco
    Deshpande, Vikram
    Tzatsos, Alexandros
    Conrad, Claudius
    Benes, Cyril H.
    Levy, David E.
    Settleman, Jeffrey
    Engelman, Jeffrey A.
    Bardeesy, Nabeel
    [J]. CANCER RESEARCH, 2011, 71 (14) : 5020 - 5029
  • [28] Targeting Glycosylation: A New Road for Cancer Drug Discovery
    Costa, Ana Filipa
    Campos, Diana
    Reis, Celso A.
    Gomes, Catarina
    [J]. TRENDS IN CANCER, 2020, 6 (09): : 757 - 766
  • [29] Protein post-translational modifications in auxin signaling
    Cui, Xiankui
    Wang, Junxia
    Li, Ke
    Lv, Bingsheng
    Hou, Bingkai
    Ding, Zhaojun
    [J]. JOURNAL OF GENETICS AND GENOMICS, 2024, 51 (03) : 279 - 291
  • [30] STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
    Deng, Liufu
    Liang, Hua
    Xu, Meng
    Yang, Xuanming
    Burnette, Byron
    Arina, Ainhoa
    Li, Xiao-Dong
    Mauceri, Helena
    Beckett, Michael
    Darga, Thomas
    Huang, Xiaona
    Gajewski, Thomas F.
    Chen, Zhijian J.
    Fu, Yang-Xin
    Weichselbaum, Ralph R.
    [J]. IMMUNITY, 2014, 41 (05) : 843 - 852
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