Advances in clinical translation of stem cell-based therapy in neurological diseases

被引：2

作者：

Wang, Yu ^{[1
]}

Cao, Yirong ^{[1
,2
,3
]}

Xie, Wanqing ^{[1
,2
,3
]}

Guo, Yunlu ^{[1
,2
,3
]}

Cai, Jiayi ^{[1
]}

Huang, Tingting ^{[1
,2
,3
]}

Li, Peiying ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Clin Res Ctr, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Anesthesiol, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Anesthesiol, Shanghai, Peoples R China

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2025年 / 45卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Neurological disorder; neurodegenerative disease; stem cell-based therapy; stem cell; MESENCHYMAL STROMAL CELLS; MARROW MONONUCLEAR-CELLS; PARKINSONS-DISEASE; DOPAMINE NEURONS; ISCHEMIC-STROKE; SERTOLI-CELLS; INTRAVENOUS TRANSPLANTATION; CEREBRAL-ISCHEMIA; VITAMIN-C; DELIVERY;

D O I：

10.1177/0271678X251317374

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stem cell-based therapies have raised considerable interest to develop regenerative treatment for neurological disorders with high disability. In this review, we focus on recent preclinical and clinical evidence of stem cell therapy in the treatment of degenerative neurological diseases and discuss different cell types, delivery routes and biodistribution of stem cell therapy. In addition, recent advances of mechanistic insights of stem cell therapy, including functional replacement by exogenous cells, immunomodulation and paracrine effects of stem cell therapies are also demonstrated. Finally, we also highlight the adjunction approaches that has been implemented to augment their reparative function, survival and migration to target specific tissue, including stem cell preconditioning, genetical engineering, co-transplantation and combined therapy.

引用

页码：600 / 616

页数：17

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