PET tracers in glioblastoma: Toward neurotheranostics as an individualized medicine approach

被引：8

作者：

Dadgar, Habibullah ^{[1
]}

Jokar, Narges ^{[2
]}

Nemati, Reza ^{[3
]}

Larvie, Mykol ^{[4
]}

Assadi, Majid ^{[2
]}

机构：

[1] Imam Reza Int Univ, Razavi Hosp, Canc Res Ctr, Mashhad, Iran

[2] Bushehr Univ Med Sci, Bushehr Med Univ Hosp, Persian Gulf Nucl Med Res Ctr, Sch Med,Dept Mol Imaging & Theranost, Bushehr, Iran

[3] Bushehr Univ Med Sci, Sch Med, Bushehr Med Univ Hosp, Dept Neurol, Bushehr, Iran

[4] Cleveland Clin, Dept Radiol, Cleveland, OH USA

来源：

FRONTIERS IN NUCLEAR MEDICINE | 2023年 / 3卷

关键词：

theranostics; neuro-Oncology; glioblastoma multiform (GBM); prostate-specific membrane antigen (PSMA); fibroblast activated protein (FAP); somatostatin receptors (SRS); chemokine receptor-4 (CXCR4); POSITRON-EMISSION-TOMOGRAPHY; PERIPHERAL BENZODIAZEPINE-RECEPTORS; HIGH-GRADE GLIOMA; AMINO-ACID PET; BRAIN-TUMORS; MEMBRANE ANTIGEN; INTEGRIN ALPHA-V-BETA-3; IMAGING PROLIFERATION; IN-VIVO; F-18-FLUOROMISONIDAZOLE PET;

D O I：

10.3389/fnume.2023.1103262

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Over the past decade, theragnostic radiopharmaceuticals have been used in nuclear medicine for both diagnosis and treatment of various tumors. In this review, we carried out a literature search to investigate and explain the role of radiotracers in the theragnostic approach to glioblastoma multiform (GBM). We primarily focused on basic and rather common positron emotion tomography (PET) radiotracers in these tumors. Subsequently, we introduced and evaluated the preclinical and clinical results of theranostic-based biomarkers including integrin receptor family, prostate-specific membrane antigen (PSMA), fibroblast activated protein (FAP), somatostatin receptors (SRS), and chemokine receptor-4 (CXCR4) for patients with GBM to confer the benefit of personalized therapy. Moreover, promising research opportunities that could have a profound impact on the treatment of GBM over the next decade are also highlighted. Preliminary results showed the potential feasibility of the theragnostic approach using theses biomarkers in GBM patients.

引用

页数：13

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