Omics studies in Behçet's disease

Purpose of review In this review, we aimed to highlight recent findings from "-omics" studies in Beh & ccedil;et's disease. Recent findings Recent genomic studies in Beh & ccedil;et's disease identified possible risk loci associated with Beh & ccedil;et's disease related uveitis, neurologic involvement and gastrointestinal involvement. Additionally, sex-specific genetic effects were determined in Beh & ccedil;et's disease. Transcriptomic analyses of immune cells in Beh & ccedil;et's disease revealed that key inflammatory pathways such as NF-kappa B and MAPK have roles in Beh & ccedil;et's disease pathogenesis. Proteomic studies have highlighted the role of immune cell derived extracellular vesicles and identified potential biomarkers for vascular involvement and examined HLA I-bound immunopeptidomes. Metabolomics studies are still limited, but recent research has pointed to alterations in fatty acid metabolism and lipid profiles in Beh & ccedil;et's disease patient. Summary Omics studies have gained importance in the field of Beh & ccedil;et's disease through the generation of large data sets and efforts to extend their application are intensifying. These studies can provide opportunities for understanding Beh & ccedil;et's disease pathogenesis when they lead to testable hypotheses. Current challenges include the choice of appropriately homogeneous patient and control groups, effective data management and sharing, high cost and a rapidly increasing gap between the wealth of observational data generated and the relative paucity of controlled experimental efforts that could lead to mechanistic understanding.