Macrophages in inflammatory skin diseases and skin tumors

被引：0

作者：

Liu, Si-Han ^{[1
]}

Zhang, Jie ^{[1
]}

Zuo, Ya-Gang ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Natl Clin Res Ctr Dermatol & Immunol Dis, Dept Dermatol,State Key Lab Complex Severe & Rare, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

北京市自然科学基金;

关键词：

macrophage; inflammatory skin diseases; skin tumors; pathogenesis; treatment; MIGRATION INHIBITORY FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ATOPIC-DERMATITIS; SERUM-LEVELS; DENDRITIC CELLS; M2; MACROPHAGES; LESIONAL SKIN; MOUSE MODEL; EXPRESSION; POLARIZATION;

D O I：

10.3389/fimmu.2024.1430825

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma. We aim to contribute to illustrating the pathogenesis and potential new therapies for inflammatory skin diseases and skin tumors from the perspective of macrophages.

引用

页数：14

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