Macrophages in inflammatory skin diseases and skin tumors

被引：0

作者：

Liu, Si-Han ^{[1
]}

Zhang, Jie ^{[1
]}

Zuo, Ya-Gang ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Natl Clin Res Ctr Dermatol & Immunol Dis, Dept Dermatol,State Key Lab Complex Severe & Rare, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

北京市自然科学基金;

关键词：

macrophage; inflammatory skin diseases; skin tumors; pathogenesis; treatment; MIGRATION INHIBITORY FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ATOPIC-DERMATITIS; SERUM-LEVELS; DENDRITIC CELLS; M2; MACROPHAGES; LESIONAL SKIN; MOUSE MODEL; EXPRESSION; POLARIZATION;

D O I：

10.3389/fimmu.2024.1430825

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma. We aim to contribute to illustrating the pathogenesis and potential new therapies for inflammatory skin diseases and skin tumors from the perspective of macrophages.

引用

页数：14

共 138 条

[1] Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions [J].

Adachi, Akimasa ;

Honda, Tetsuya ;

Egawa, Gyohei ;

Kanameishi, Shuto ;

Takimoto, Riko ;

Miyake, Toshiya ;

Hossain, Md Razib ;

Komine, Mayumi ;

Ohtsuki, Mamitaro ;

Gunzer, Matthias ;

Ikuta, Koichi ;

Kabashima, Kenji .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 150 (04) :909-+

[2] Role of Human Macrophage Polarization in Inflammation during Infectious Diseases [J].

Atri, Chiraz ;

Guerfali, Fatma Z. ;

Laouini, Dhafer .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (06)

[3] Stage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides [J].

Atzmony, Lihi ;

Moyal, Lilach ;

Feinmesser, Meora ;

Gorovitz, Batya ;

Hirshberg, Avraham ;

Amitay-Laish, Iris ;

Prag-Naveh, Hadas ;

Barzilai, Aviv ;

Hodak, Emmilia .

ACTA DERMATO-VENEREOLOGICA, 2020, 100 :1-7

[4] Effects of Ruxolitinib on fibrosis in preclinical models of systemic sclerosis [J].

Bellamri, Nessrine ;

Lelong, Marie ;

Joannes, Audrey ;

Le Tallec, Erwan ;

Jouneau, Stephane ;

Vernhet, Laurent ;

Lescoat, Alain ;

Lecureur, Valerie .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 116

[5] Human dermal fibroblast-derived exosomes induce macrophage activation in systemic sclerosis [J].

Bhandari, Rajan ;

Yang, Heetaek ;

Kosarek, Noelle N. ;

Smith, Avi E. ;

Garlick, Jonathan A. ;

Hinchcliff, Monique ;

Whitfield, Michael L. ;

Pioli, Patricia A. .

RHEUMATOLOGY, 2023, 62 :SI114-SI124

[6] Profibrotic Activation of Human Macrophages in Systemic Sclerosis [J].

Bhandari, Rajan ;

Ball, Michael S. ;

Martyanov, Viktor ;

Popovich, Dillon ;

Schaafsma, Evelien ;

Han, Saemi ;

ElTanbouly, Mohamed ;

Orzechowski, Nicole M. ;

Carns, Mary ;

Arroyo, Esperanza ;

Aren, Kathleen ;

Hinchcliff, Monique ;

Whitfield, Michael L. ;

Pioli, Patricia A. .

ARTHRITIS & RHEUMATOLOGY, 2020, 72 (07) :1160-1169

[7] Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: correlates with decreased serum levels of complement [J].

Bijl, M ;

Reefman, E ;

Horst, G ;

Limburg, PC ;

Kallenberg, CGM .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (01) :57-63

[8] Molecular and Morphological Characterization of Inflammatory Infiltrate in Rosacea Reveals Activation of Th1/Th17 Pathways [J].

Buhl, Timo ;

Sulk, Mathias ;

Nowak, Pawel ;

Buddenkotte, Joerg ;

McDonald, Ian ;

Aubert, Jerome ;

Carlavan, Isabelle ;

Deret, Sophie ;

Reiniche, Pascale ;

Rivier, Michel ;

Voegel, Johannes J. ;

Steinhoff, Martin .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (09) :2198-2208

[9] ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model [J].

Cao, Dianyu ;

Zheng, Jina ;

Li, Zheng ;

Yu, Yong ;

Chen, Zengrui ;

Wang, Qiang .

ARTHRITIS RESEARCH & THERAPY, 2023, 25 (01)

[10] Keratinocyte derived HMGB1 aggravates psoriasis dermatitis via facilitating inflammatory polarization of macrophages and hyperproliferation of keratinocyte [J].

Chen, Jing ;

Fu, Yuxuan ;

Xiong, Sidong .

MOLECULAR IMMUNOLOGY, 2023, 163 :1-12

← 1 2 3 4 5 6 7 8 9 10 →