Emerging Oral Pharmaceuticals for Dry Age-Related Macular Degeneration: Mechanism of Action, Current Clinical Status, and Future Directions

被引：0

作者：

Deboer, Charles M. T. ^{[1
,2
,3
]}

Rasmussen, Ditte K. ^{[1
,2
]}

Franco, Joel A. ^{[1
,2
]}

Mahajan, Vinit B. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Mol Surg Lab, Stanford, CA USA

[2] Stanford Univ, Byers Eye Inst, Dept Ophthalmol, Stanford, CA USA

[3] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA

来源：

OPHTHALMIC SURGERY LASERS & IMAGING RETINA | 2024年 / 55卷 / 09期

关键词：

GEOGRAPHIC ATROPHY; VISUAL CYCLE; EMIXUSTAT HYDROCHLORIDE; DRUSEN; DOXYCYCLINE; FENRETINIDE; DANICOPAN; ACU-4429; PHASE-1; SAFETY;

D O I：

10.3928/23258160-20240430-02

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Dry age-related macular degeneration (AMD) has been historically managed with lifestyle modifications, monitoring for conversion to wet AMD, and vitamins. Recently there has been a flurry of research focused on discovering new targets to prevent worsening of dry AMD. In 2023, the US Food and Drug Administration approved the first two intravitreal complement inhibitors to slow the rate of geographic atrophy progression. However, serial intravitreal injections for a chronic progressive disease are burdensome for patients and have procedural risks. Therefore, there is significant research to discover novel oral medications to manage dry AMD. Several oral medications are currently in phase 2 and 3 clinical trials for dry AMD, whereas others have had recent readouts on their clinical trials and efficacy. The purpose of this review is to describe the therapeutic pathways currently being investigated and to provide an update on the clinical status of novel oral medications for the management of dry AMD.

引用

页码：528 / 534

页数：7

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