Uridine Phosphorylase 1 as a Biomarker Associated with Glycolysis in Acute Lung Injury

被引:0
作者
Song, Congkuan [1 ,2 ]
Li, Qingqing [3 ]
Zhang, Jinjin [4 ]
Hu, Weidong [1 ,2 ]
机构
[1] Wuhan Univ, Dept Cardiol, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Peoples R China
[2] Hubei Prov Clin Res Ctr Canc, 169 Donghu Rd, Wuhan 430071, Peoples R China
[3] Wuhan Univ, Dept Resp & Crit Care Med, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China
[4] Wuhan Fourth Hosp, Dept Crit Care Med, Wusheng Rd, Wuhan 430033, Peoples R China
关键词
Acute lung injury (ALI); LPS; UPP1; Glycolysis; LIPOPOLYSACCHARIDE; METABOLISM; MACROPHAGE;
D O I
10.1007/s10753-025-02270-z
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The specific pathogenesis of acute lung injury (ALI) is complex and not yet clear, and the clinical treatment methods are relatively limited. It is of great clinical significance to explore its pathogenesis and effective molecular targets. Here, we identified an ALI biomarker (UPP1) associated with uridine metabolism by a systematic bioinformatics approach. It was also confirmed to be associated with the glycolytic pathway in the mouse ALI model. In addition, drug sensitivity analysis based on the CMAP database identified three UPP1-associated drugs (CAY10585, XL147 and IOX2) that may be useful in the treatment of ALI. Molecular docking and molecular dynamics simulations further confirmed the stability of the binding between UPP1 and the three drugs. In conclusion, this study confirms that the uridine metabolism gene UPP1 associated with glycolysis is a key biomarker of ALI and provides valuable insights into the potential application of CAY10585, XL147 and IOX2 in ALI.
引用
收藏
页数:13
相关论文
共 34 条
[1]   Regulatory T cell-mediated resolution of lung injury: identification of potential target genes via expression profiling [J].
Aggarwal, Neil R. ;
D'Alessio, Franco R. ;
Tsushima, Kenji ;
Sidhaye, Venkataramana K. ;
Cheadle, Christopher ;
Grigoryev, Dmitry N. ;
Barnes, Kathleen C. ;
King, Landon S. .
PHYSIOLOGICAL GENOMICS, 2010, 41 (02) :109-119
[2]   Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation [J].
Altemeier, WA ;
Matute-Bello, G ;
Gharib, SA ;
Glenny, RW ;
Martin, TR ;
Liles, WC .
JOURNAL OF IMMUNOLOGY, 2005, 175 (05) :3369-3376
[3]   Integrated genomic characterization of IDH1-mutant glioma malignant progression [J].
Bai, Hanwen ;
Harmanci, Akdes Serin ;
Erson-Omay, E. Zeynep ;
Li, Jie ;
Coskun, Sueleyman ;
Simon, Matthias ;
Krischek, Boris ;
Ozduman, Koray ;
Omay, S. Buelent ;
Sorensen, Eric A. ;
Turcan, Sevin ;
Bakirciglu, Mehmet ;
Carrion-Grant, Geneive ;
Murray, Phillip B. ;
Clark, Victoria E. ;
Ercan-Sencicek, A. Gulhan ;
Knight, James ;
Sencar, Leman ;
Altinok, Selin ;
Kaulen, Leon D. ;
Guelez, Burcu ;
Timmer, Marco ;
Schramm, Johannes ;
Mishra-Gorur, Ketu ;
Henegariu, Octavian ;
Moliterno, Jennifer ;
Louvi, Angeliki ;
Chan, Timothy A. ;
Tannheimer, Stacey L. ;
Pamir, M. Necmettin ;
Vortmeyer, Alexander O. ;
Bilguvar, Kaya ;
Yasuno, Katsuhito ;
Guenel, Murat .
NATURE GENETICS, 2016, 48 (01) :59-+
[4]   The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity [J].
Canto, Caries ;
Houtkooper, Riekelt H. ;
Pirinen, Eija ;
Youn, Dou Y. ;
Oosterveer, Maaike H. ;
Cen, Yana ;
Fernandez-Marcos, Pablo J. ;
Yamamoto, Hiroyasu ;
Andreux, Penelope A. ;
Cettour-Rose, Philippe ;
Gademann, Karl ;
Rinsch, Chris ;
Schoonjans, Kristina ;
Sauve, Anthony A. ;
Auwerx, Johan .
CELL METABOLISM, 2012, 15 (06) :838-847
[5]   Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene [J].
Cao, DL ;
Leffert, JJ ;
McCabe, J ;
Kim, B ;
Pizzorno, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (22) :21169-21175
[6]   Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis [J].
Codo, Ana Campos ;
Davanzo, Gustavo Gastao ;
Monteiro, Lauar de Brito ;
de Souza, Gabriela Fabiano ;
Muraro, Stefanie Primon ;
Virgilio-da-Silva, Joao Victor ;
Prodonoff, Juliana Silveira ;
Carregari, Victor Corasolla ;
Oliveira de Biagi Junior, Carlos Alberto ;
Crunfli, Fernanda ;
Jimenez Restrepo, Jeffersson Leandro ;
Vendramini, Pedro Henrique ;
Reis-de-Oliveira, Guilherme ;
dos Santos, Karina Bispo ;
Toledo-Teixeira, Daniel A. ;
Parise, Pierina Lorencini ;
Martini, Matheus Cavalheiro ;
Marques, Rafael Elias ;
Carmo, Helison R. ;
Borin, Alexandre ;
Coimbra, Lais Durco ;
Boldrini, Vinicius O. ;
Brunetti, Natalia S. ;
Vieira, Andre S. ;
Mansour, Eli ;
Ulaf, Raisa G. ;
Bernardes, Ana F. ;
Nunes, Thyago A. ;
Ribeiro, Luciana C. ;
Palma, Andre C. ;
Agrela, Marcus, V ;
Moretti, Maria Luiza ;
Sposito, Andrei C. ;
Pereira, Fabricio Biscaro ;
Velloso, Licio Augusto ;
Ramirez Vinolo, Marco Aurelio ;
Damasio, Andre ;
Proenca-Modena, Jose Luiz ;
Carvalho, Robson Francisco ;
Mori, Marcelo A. ;
Martins-de-Souza, Daniel ;
Nakaya, Helder, I ;
Farias, Alessandro S. ;
Moraes-Vieira, Pedro M. .
CELL METABOLISM, 2020, 32 (03) :437-+
[7]   Therapeutic effect of uridine phosphorylase 1 (UPP1) inhibitor on liver fibrosis in vitro and in vivo [J].
Goncalves da Silva, Elisa Feller ;
Costa, Bruna Pasqualotto ;
Nassr, Marcella Tornquist ;
Basso, Bruno de Souza ;
Bastos, Matheus Scherer ;
Antunes, Gessica Luana ;
Reghelin, Camille Kirinus ;
Rosa Garcia, Maria Claudia ;
Schneider Levorse, Vitor Giancarlo ;
Carlessi, Leonardo Pfeiff ;
Antunes Fernandes, Krist Helen ;
Richter Schmitz, Carine Raquel ;
Haute, Gabriela Viegas ;
Luft, Carolina ;
Santarem, Eliane ;
Barbe-Tuana, Florencia Maria ;
Fagundes Donadio, Marcio Vinicius ;
Basso, Luiz Augusto ;
Machado, Pablo ;
de Oliveira, Jarbas Rodrigues .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 890
[8]   Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions [J].
Hamasaki, Mike Yoshio ;
Severino, Patricia ;
Puga, Renato David ;
Koike, Marcia Kiyomi ;
Hernandes, Camila ;
Barbeiro, Hermes Vieira ;
Barbeiro, Denise Frediani ;
Cesar Machado, Marcel Cerqueira ;
Reis, Eduardo Moraes ;
da Silva, Fabiano Pinheiro .
INFLAMMATION, 2019, 42 (03) :1023-1031
[9]   Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury [J].
He, Hao ;
Yang, Wu ;
Su, Nan ;
Zhang, Chuankai ;
Dai, Jianing ;
Han, Feng ;
Singhal, Mahak ;
Bai, Wenjuan ;
Zhu, Xiaolan ;
Zhu, Jing ;
Liu, Zhen ;
Xia, Wencheng ;
Liu, Xiaoting ;
Zhang, Chonghe ;
Jiang, Kai ;
Huang, Wenhui ;
Chen, Dan ;
Wang, Zhaoyin ;
He, Xueyang ;
Kirchhoff, Frank ;
Li, Zhenyu ;
Liu, Cong ;
Huan, Jingning ;
Wang, Xiaohong ;
Wei, Wu ;
Wang, Jing ;
Augustin, Hellmut G. ;
Hu, Junhao .
JOURNAL OF EXPERIMENTAL MEDICINE, 2022, 220 (02)
[10]   Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses [J].
Hu, Qian ;
Lyon, Christopher J. ;
Fletcher, Jesse K. ;
Tang, Wenfu ;
Wan, Meihua ;
Hu, Tony Y. .
ACTA PHARMACEUTICA SINICA B, 2021, 11 (06) :1493-1512