B/N-doped carbon nano-onions as nanocarriers for targeted breast cancer therapy

被引：0
作者：
Mohan, Hugh [1 ]
Salaroglio, Iris Chiara [2 ,3 ]
Bartkowski, Michal [1 ]
Courtney, Kellyjean [1 ]
Andreana, Ilaria [4 ]
Limongi, Tania [4 ]
Arenal, Raul [5 ,6 ,7 ]
Riganti, Chiara [2 ,3 ]
Arpicco, Silvia [4 ]
Giordani, Silvia [1 ]
机构：
[1] Dublin City Univ, Sch Chem Sci, Lonsdale Bldg, Dublin, Ireland
[2] Dept Oncol, Piazza Nizza 44, I-10126 Turin, Italy
[3] Mol Biotechnol Ctr G Tarone, Piazza Nizza 44, I-10126 Turin, Italy
[4] Dept Drug Sci & Technol, Via Pietro Giuria 9, I-10125 Turin, Italy
[5] CSIC U Zaragoza, Inst Nanociencia & Mat Aragon INMA, Zaragoza 50009, Spain
[6] Univ Zaragoza, Lab Microscopias Avanzadas LMA, Zaragoza 50018, Spain
[7] ARAID Fdn, Zaragoza 50018, Spain
来源：
NANOSCALE | 2025年
基金：
爱尔兰科学基金会;
关键词：
DELIVERY; CELLS;
D O I：
10.1039/d4nr04990j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cancer is one of the leading causes of death worldwide and represents a significant burden on global health systems. Many existing chemotherapy treatments come with severe side effects, ranging from hair loss to cardiotoxicity, and many types of cancer express chemotherapy resistance, such as triple-negative breast cancer. This study presents a novel boron/nitrogen-doped carbon nano-onion (BN-CNO) based nanocarrier system that can deliver doxorubicin (DOX) to cancer cells via a pH-dependent drug release mechanism. The nanocarrier formulation consists of a hyaluronic acid/phospholipid conjugate (HA-DMPE) that is non-covalently bound to the BN-CNOs upon which DOX is loaded via pi-pi stacking interactions. The HA-DMPE/BN-CNO/DOX system enhances the uptake and anticancer effects of DOX in MDA-MB-468 and MDA-MB-231 TNBC cells whilst reducing the cardiotoxicity of DOX in AC-16 human cardiomyocytes.
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页数：16
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