Photomediated One-Pot Multicomponent Cascade Reaction for the Synthesis of N-Acyl/Sulfonyl-α-Phosphonated-1,2,3,4-Tetrahydroisoquinoline via Twice Acyl/Sulfonyl Iminium Formation

被引：0

作者：

Zhang, Yun ^{[1
,2
,3
]}

Nie, Jia-Huan ^{[1
,2
,3
]}

Du, Yao ^{[1
,2
,3
]}

Ye, Xin-Rui ^{[1
,2
,3
]}

Cui, Bao-Dong ^{[1
,2
,3
]}

Mou, Xue-Qing ^{[1
,2
,3
]}

Liu, Jia-Bao ^{[4
]}

Yuan, Wei-Cheng ^{[1
,5
]}

Chen, Yong-Zheng ^{[1
,2
,3
]}

机构：

[1] Zunyi Med Univ, Sch Pharm, Green Pharmaceut Engn Res Ctr Guizhou Prov, Key Lab Biocatalysis & Chiral Drug Synth Guizhou P, Zunyi 563006, Peoples R China

[2] Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi 563006, Peoples R China

[3] Zunyi Med Univ, Minist Educ, Joint Int Res Lab Ethnomed, Zunyi 563006, Peoples R China

[4] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

[5] Chengdu Univ, Inst Adv Study, Res Ctr Chiral Drugs, Chengdu 610106, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2025年 / 20卷 / 09期

关键词：

1-Phosphonated N-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines; Photomediated redox; One-pot multicomponent cascade reaction; Twice acyl/sulfonyl iminium intermediate strategy; AMINOPHOSPHONIC ACIDS; ASYMMETRIC-SYNTHESIS; HETEROCYCLES; DESIGN; ROUTE;

D O I：

10.1002/asia.202401542

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-acyl/sulfonyl-alpha-phosphonated 1,2,3,4-tetrahydroiso-quinolines (THIQs) are significant structural motifs in organic synthesis and drug discovery. However, the one-pot approach enabling direct difunctionalization of THIQs remains challenging. Herein we report a photomediated one-pot multicomponent cascade reaction to access N-acyl/sulfonyl-alpha-phosphonated THIQs via twice acyl/sulfonyl iminium. This method features air as an oxidant, high atom and step economy, and mild conditions.

引用

页数：5

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