The Association Between IL-8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer

被引：1

作者：

Xu, Bin ^{[1
]}

Yan, Yidan ^{[2
]}

机构：

[1] Jiangnan Univ, Affiliated Hosp, Geriatr Dept, Wuxi, Peoples R China

[2] Jiangnan Univ, Affiliated Hosp, Med Oncol, Wuxi, Peoples R China

来源：

CANCER REPORTS | 2025年 / 8卷 / 01期

关键词：

biomarker; cancer susceptibility; gastric cancer; IL-8; polymorphism; SINGLE NUCLEOTIDE POLYMORPHISMS; INFLAMMATORY RESPONSE GENES; NECROSIS-FACTOR-ALPHA; THAN-A POLYMORPHISM; CELL LUNG-CANCER; INTERLEUKIN-8; GENE; HELICOBACTER-PYLORI; BREAST-CANCER; COMMON POLYMORPHISMS; PROSTATE-CANCER;

D O I：

10.1002/cnr2.70103

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundChanges in functional genetic polymorphisms may increase or decrease the risk of cancer in patients. Nowadays, the association between polymorphisms in the interleukin-8 (IL-8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relationships remain unclear.AimThe current study aims to comprehensively evaluate the association between IL-8 gene six polymorphisms and the whole cancer risk, especially -251 polymorphism and gastric cancer.Methods and ResultsSix polymorphisms (-251, -353, +678, +1633, +2767, +781) were collected. The expression of serum IL-8 was calculated by ELISA assay. First, 104 case-control studies were conducted. Second, this research has made significant discoveries regarding the -251, -353 and +781 polymorphisms and the potential associations with cancer risk. Finally, the serum IL-8 levels in gastric cancer patients with AA/TT genotypes were significantly higher than those with the same genotypes of healthy controls and TT genotypes in gastric cancer patients.ConclusionOverall, the investigation has revealed that IL-8 gene polymorphisms significantly influence vulnerability to cancer development, especially for gastric cancer.

引用

页数：22

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