Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water

被引：0

作者：

Chang, Wei-Jin ^{[1
]}

Liew, Sook Yee ^{[2
]}

Kurz, Thomas ^{[3
]}

Tan, Siow-Ping ^{[1
]}

机构：

[1] Tunku Abdul Rahman Univ Management & Technol, Fac Appl Sci, Dept Phys Sci, Kuala Lumpur 53300, Malaysia

[2] Univ Malaya, Ctr Fdn Studies Sci, Kuala Lumpur 50603, Malaysia

[3] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut & Med Chem, D-40225 Dusseldorf, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 21卷

关键词：

amino acids; hydantoin; microwave-assisted; one-pot reaction; Urech synthesis; 5,5'-DISUBSTITUTED HYDANTOINS;

D O I：

10.3762/bjoc.21.46

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hydantoin scaffold is renowned for its wide-ranging biological activities, including antibacterial, antiviral, anticancer, antiinflammatory, and anticonvulsant effects. In this study, we present an innovative, sustainable approach to synthesizing hydantoins (H2a-j) directly from amino acids. This method employs a column chromatography-free, two-step, one-pot microwave-assisted synthesis that delivers hydantoins in yields ranging from 34% to 89%. The protocol demonstrates exceptional functional group tolerance, accommodating phenyl, aliphatic, phenol, alcohol, heterocyclic, and sulfide groups. This scalable, rapid, and eco-friendly strategy offers a promising avenue for the efficient synthesis of hydantoins, aligning with green chemistry principles and expanding the accessibility of these bioactive compounds for pharmaceutical applications.

引用

页码：596 / 600

页数：5

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