Measuring the Interrelationships Between Cognitive Performance, Race/Ethnicity, Discrimination, Health Behaviors, and Physiological Dysregulation: A Path Analysis of the Multi-Ethnic Study of Atherosclerosis

被引：0
作者：
Forrester, Sarah N. [1 ]
Gallo, Joseph J. [2 ]
Leoutsakos, Jeannie-Marie [3 ]
Thorpe Jr, Roland J. [4 ]
Hughes, Timothy M. [5 ]
Fitzpatrick, Annette L. [6 ]
Rapp, Stephen R. [7 ]
Seeman, Teresa E. [8 ]
机构：
[1] Univ Massachusetts, Chan Med Sch, Dept Populat & Quantitat Hlth Sci, Worcester, MA USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Neuropsychiat, Baltimore, MD USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA
[5] Wake Forest Univ, Bowman Gray Sch Med, Gerontol & Geriatr Med, Winston Salem, NC USA
[6] Univ Washington, Bowman Gray Sch Publ Hlth, Dept Epidemiol, Seattle, WA USA
[7] Wake Forest Univ, Bowman Gray Sch Med, Psychiat & Behav Med, Winston Salem, NC USA
[8] UCLA, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA
来源：
JOURNAL OF AGING AND HEALTH | 2025年 / 37卷 / 3-4_SUPPL期
关键词：
physiological dysregulation; discrimination; cognition; health behaviors; ALLOSTATIC LOAD; RACIAL-DISCRIMINATION; AFRICAN-AMERICAN; OLDER-ADULTS; LIFE-COURSE; DISPARITIES; STRESS; RACE; EDUCATION; MIDLIFE;
D O I：
10.1177/08982643241309457
中图分类号：
R4 [临床医学]; R592 [老年病学];
学科分类号：
1002 ; 100203 ; 100602 ;
摘要：
ObjectiveThe objective of this study was to examine the interrelationships between cognitive performance, race/ethnicity, discrimination, health behaviors, and physiological dysregulation.MethodsWe used data from the Multi-Ethnic Study of Atherosclerosis (MESA) (N = 1667). We used path analyses to examine the association between discrimination, physiological dysregulation, health behaviors, and cognitive performance using the Cognitive Ability Screening Instrument (CASI) at Exam 5 (2010-12) and Exam 6 (2016-18). We examined the relationship between discrimination at Exam 1 (2000-02) and physiological dysregulation at Exam 5. We used overall and ethnoracial-stratified path analysis. All models were adjusted for age, sex, site, depression, stress, socioeconomic status, and APOE-e4.ResultsPhysiological dysregulation was associated with worse cognitive performance in the full sample and among the White ethnoracial subgroup. Everyday discrimination was associated with better cognitive performance among Black participants.DiscussionAssociations between discrimination, physiological dysregulation, and cognitive performance vary and should be examined longitudinally.
引用
收藏
页码：40S / 52S
页数：13
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