Fabrication of pH- and Ultrasound-Responsive Polymeric Micelles: The Effect of Amphiphilic Block Copolymers with Different Hydrophilic/Hydrophobic Block Ratios for Self-Assembly and Controlled Drug Release

被引：0
作者：
Wei, Hong-Xiang [1 ]
Liu, Ming-Hsin [2 ]
Wang, Tzu-Ying [1 ]
Shih, Meng-Hsiu [2 ]
Yu, Jiashing [2 ]
Yeh, Yi-Cheun [1 ]
机构：
[1] Natl Taiwan Univ, Inst Polymer Sci & Engn, Taipei 10617, Taiwan
[2] Natl Taiwan Univ, Dept Chem Engn, Taipei 10617, Taiwan
来源：
BIOMACROMOLECULES | 2025年
关键词：
BIODEGRADABLE POLYMERSOMES; DELIVERY; DOXORUBICIN; CARRIERS; THERAPY; SYSTEMS;
D O I：
10.1021/acs.biomac.4c01202
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stimuli-responsive polymeric vehicles can change their physical or chemical properties when exposed to internal or external triggers, enabling precise spatiotemporal control of drug release. Nevertheless, systematic research is lacking in preparing dual stimuli-responsive amphiphilic block copolymers with different hydrophilic/hydrophobic block ratios in forming self-assembled structures. Here, we synthesized two types of block copolymers consisting of the hydrophobic segments (i.e., pH-responsive 2-(diethylamino)ethyl methacrylate (DEA) and ultrasound-responsive 2-methoxyethyl methacrylate (MEMA)) and hydrophilic poly(ethylene glycol) methyl ether (mPEG) segments, forming mPEGX-b-P(DEAY-co-MEMAZ). These amphiphilic block copolymers can self-assemble to form polymeric micelles, and their structures (e.g., size) and properties (e.g., critical vesicle concentration, stability, stimuli-responsiveness to pH and ultrasound, drug loading efficiency, and controlled drug release performance) were thoroughly investigated. In vitro cell studies further demonstrate that ultrasound can efficiently trigger drug release from polymeric micelles, emphasizing their potential for controlled drug delivery in therapeutic applications.
引用
收藏
页码：2116 / 2130
页数：15
相关论文
共 81 条
  • [1] Chauhan A.S., Dendrimers for drug delivery, Molecules, 23, 4, (2018)
  • [2] Zhang S., Xu Y., Wang B., Qiao W., Liu D., Li Z., Cationic compounds used in lipoplexes and polyplexes for gene delivery, J. Controlled Release, 100, 2, pp. 165-180, (2004)
  • [3] Kuperkar K., Patel D., Atanase L.I., Bahadur P., Amphiphilic block copolymers: their structures, and self-assembly to polymeric micelles and polymersomes as drug delivery vehicles, Polymers, 14, 21, (2022)
  • [4] Singh V., Md S., Alhakamy N.A., Kesharwani P., Taxanes loaded polymersomes as an emerging polymeric nanocarrier for cancer therapy, Eur. Polym. J., 162, (2022)
  • [5] Trubetskoy V.S., Polymeric micelles as carriers of diagnostic agents, Adv. Drug Delivery Rev., 37, 1-3, pp. 81-88, (1999)
  • [6] Dai Y., Chen X., Zhang X., Recent advances in stimuli-responsive polymeric micelles via click chemistry, Polym. Chem., 10, 1, pp. 34-44, (2019)
  • [7] Croy S.R., Kwon G.S., The effects of Pluronic block copolymers on the aggregation state of nystatin, J. Controlled Release, 95, 2, pp. 161-171, (2004)
  • [8] Roy S., Zhang K., Roth T., Vinogradov S., Kao R.S., Kabanov A., Reduction of fibronectin expression by intravitreal administration of antisense oligonucleotides, Nat. Biotechnol., 17, 5, pp. 476-479, (1999)
  • [9] Perumal S., Atchudan R., Lee W., A review of polymeric micelles and their applications, Polymers, 14, 12, (2022)
  • [10] Zhu Y., Cao S., Huo M., van Hest J.C., Che H., Recent advances in permeable polymersomes: fabrication, responsiveness, and applications, Chem. Sci., 14, 27, pp. 7411-7437, (2023)
123456789