A Comprehensive and Concise Review on Significance of Potent Peptide; Amyloid Beta (Aβ) in Progression of Alzheimer's Disease

Background A condition associated with neurodegeneration is termed Alzheimer's, characterized by mental as well as memory deterioration. Amyloid beta (A beta) is a type of peptide that accumulates within the central nervous system and causes plaque, cerebral amyloid angiopathy (CAA), and neurodegeneration (loss of acetylcholine). These peptide forms have a major impact on neuronal damage.Objective Our goal is to provide an overview of A beta's potential involvement in developing Alzheimer's condition.Methods An extensive literature review was done using the standard keywords "amyloid beta", "amyloid beta precursor protein", "secretase", and "Alzheimer's disease" from the databases SCOPUS, PubMed, Elsevier, and Web of Science.Conclusion Amyloid-beta precursor protein (A beta PP) is converted to A beta through a series of divisions by beta and gamma secretases, which are found in lipid rafts. The control of these elements is believed to have a significant role in A beta production throughout the aetiology of Alzheimer's disease (AD). In conclusion, research on A beta aggregation and clearance has been active in preventing and curing Alzheimer's disorders. Thus, the purpose of this article was to describe the pharmacological function of A beta peptide plus its process of aggregation.