Structure, Properties, and Biomedical Activity of Natural Sweeteners Steviosides: An Update

被引：1
作者：
Wang, Aoyi [1 ]
Hu, Huiqin [1 ]
Yuan, Yadan [1 ]
Mei, Shiran [1 ]
Zhu, Guoxue [1 ]
Yue, Qiaoyan [1 ,2 ]
Zhang, Yanliang [1 ,2 ]
Jiang, Shujun [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Nanjing, Peoples R China
[2] Nanjing Res Ctr Infect Dis Integrated Tradit Chine, Nanjing, Peoples R China
来源：
FOOD SCIENCE & NUTRITION | 2025年 / 13卷 / 02期
关键词：
biomedical activity; safety; stevioside; STIMULATES INSULIN-SECRETION; STEVIA-REBAUDIANA BERTONI; PANCREATIC BETA-CELLS; RENAL CYST GROWTH; NF-KAPPA-B; OXIDATIVE STRESS; ORAL STEVIOSIDE; REBAUDIOSIDE-A; GLYCOSIDES; EXTRACT;
D O I：
10.1002/fsn3.70002
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Stevioside is a natural sweetener with the characteristics of low calorie and high sweetness. It comprises a diverse range of monomers that play crucial roles in numerous biological processes. Due to these attributes, it has gained widespread application in agriculture, food, and pharmaceutical industries. As a substitute for sugar, stevioside also shows good pharmacological activities on glucose metabolism, bodyweight keeping, blood pressure maintenance, and shows anti-inflammatory, anti-oxidation, anti-tumor, antibacterial, and immune regulation activities. This review summarized the update on the food safety, sweet structure-activity relationship, pharmacological activity of stevia glycosides recently, and discussed the limitations of its application in food and medicine.
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页数：23
相关论文
共 156 条
[121]  
Usami M, 1995, Eisei Shikenjo Hokoku, P31
[122]   Steviol glycosides affect functional properties and macromolecular expression of breast cancer cells [J].
Velesiotis, Christos ;
Kanellakis, Marinos ;
Vynios, Demitrios H. .
IUBMB LIFE, 2022, 74 (10) :1012-1028
[123]   Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol [J].
Voloshina, Alexandra D. ;
Sapunova, Anastasiia S. ;
Kulik, Natalia V. ;
Belenok, Mayya G. ;
Strobykina, Irina Yu ;
Lyubina, Anna P. ;
Gumerova, Syumbelya K. ;
Kataev, Vladimir E. .
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 32
[124]   Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin [J].
Wan, Junlai ;
Zhu, Ziqing ;
He, Zhiyi ;
Wu, Hua ;
Chen, Anmin ;
Zhu, Wentao ;
Cheng, Peng .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 119
[125]  
Wang J, 2019, FOOD FUNCT, V10, P1179, DOI [10.1039/c8fo01663a, 10.1039/C8FO01663A]
[126]   Effects of different levels of stevioside on growth performance, digestive enzyme activity, antioxidant capacity and gene expression of juvenile mirror carp (Cyprinus carpio) [J].
Wang, Jinge ;
Li, Kaifang ;
Wang, Liansheng ;
Xu, Qiyou .
AQUACULTURE, 2021, 543
[127]   Changes in the rumen development, rumen fermentation, and rumen microbiota community in weaned calves during steviol glycosides treatment [J].
Wang, Kexin ;
Jiang, Maocheng ;
Chen, Yuhang ;
Huang, Yuncheng ;
Cheng, Zhiqiang ;
Datsomor, Osmond ;
Jama, Shakib Mohamed ;
Zhu, Liping ;
Li, Yajing ;
Zhao, Guoqi ;
Lin, Miao .
FRONTIERS IN MICROBIOLOGY, 2024, 15
[128]   Effects of dietary stevioside/rebaudioside A on the growth performance and diarrhea incidence of weaned piglets [J].
Wang, L. S. ;
Shi, Z. ;
Shi, B. M. ;
Shan, A. S. .
ANIMAL FEED SCIENCE AND TECHNOLOGY, 2014, 187 :104-109
[129]  
Wang LM, 2019, FOOD FUNCT, V10, P7967, DOI [10.1039/C9FO02127B, 10.1039/c9fo02127b]
[130]   Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis [J].
Wang, Qian ;
Onuma, Kazuhiro ;
Liu, Changhao ;
Wong, Heidi ;
Bloom, Michelle S. ;
Elliott, Eileen E. ;
Cao, Richard R. L. ;
Hu, Nick ;
Lingampalli, Nithya ;
Sharpe, Orr ;
Zhao, Xiaoyan ;
Sohn, Dong Hyun ;
Lepus, Christin M. ;
Sokolove, Jeremy ;
Mao, Rong ;
Cisar, Cecilia T. ;
Raghu, Harini ;
Chu, Constance R. ;
Giori, Nicholas J. ;
Willingham, Stephen B. ;
Prohaska, Susan S. ;
Cheng, Zhen ;
Weissman, Irving L. ;
Robinson, William H. .
JCI INSIGHT, 2019, 4 (18)
78910111213141516