The Antiviral and Antimalarial Prodrug Artemisinin from the Artemisia Species: A Review

被引:2
作者
Das, Gitishree [1 ]
Shin, Han-Seung [2 ]
Patra, Jayanta Kumar [1 ]
机构
[1] Dongguk Univ Seoul, Res Inst Integrat Life Sci, Goyang 10326, South Korea
[2] Dongguk Univ Seoul, Dept Food Sci & Biotechnol, Goyang 10326, South Korea
关键词
artemisinin; prodrug; Artemisia annua; antiviral; antimalarial; derivatives; QUINOLINE HYBRID-DIMERS; ANTI-MALARIA DRUG; ANNUA L; IN-VITRO; PLASMODIUM-FALCIPARUM; QINGHAOSU ARTEMISININ; ASSISTED EXTRACTION; ARTESUNATE; PHARMACOLOGY; DERIVATIVES;
D O I
10.3390/cimb46110718
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Artemisinin is a truly fascinating drug in many ways. Since the unrestrained procedure of its detection, as an antimalarial drug, artemisinin has received a great deal of consideration. Recently, application of artemisinin-based combination therapy has been broadly applied for treating numerous ailments. Moreover, as an antimalarial compound, artemisinin and its associated compounds have abundant healing efficacy and can be repurposed for additional symptoms, like autoimmune infections, cancer, and viral contaminations. Recently a number of studies have highlighted the significance of the artemisinin-related compounds in SARS-CoV-2 treatment. The current review purposes to present a concise account of the history of the antiviral and antimalarial prodrugs-Artemisinin, from the Artemisia species. It is followed by its antiviral, antimalarial prospective, chemical nature and extraction procedure, photochemistry, mechanism of action, and its clinical trials and patents, and accentuates the significance of the mechanistic studies concerned for therapeutic results, both in viral and malarial circumstances.
引用
收藏
页码:12099 / 12118
页数:20
相关论文
共 154 条
[1]   Prodrug approach: An overview of recent cases [J].
Abet, Valentina ;
Filace, Fabiana ;
Recio, Javier ;
Alvarez-Builla, Julio ;
Burgos, Carolina .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 127 :810-827
[2]  
Adjuik M, 2004, LANCET, V363, P9, DOI 10.1016/S0140-6736(03)15162-8
[3]   RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment? (Retracted Article) [J].
Agrawal, Pawan K. ;
Agrawal, Chandan ;
Blunden, Gerald .
MOLECULES, 2022, 27 (12)
[4]  
Ahmad I., 2022, J. Explor. Res. Pharmacol, V7, P54, DOI [10.14218/JERP.2021.00034, DOI 10.14218/JERP.2021.00034]
[5]   Assessment of artemisinin and antioxidant activities of three wild Artemisia species of Algeria [J].
Ahmed-Laloui, Hamza ;
Zaak, Hadjer ;
Rahmani, Abderrahman ;
Kashi, Imad ;
Chemat, Smain ;
Miara, Mohamed Djamel ;
Cherb, Nora ;
Derdour, Mouna .
NATURAL PRODUCT RESEARCH, 2022, 36 (24) :6344-6352
[6]   CHEMICAL ASPECTS OF SELECTIVE TOXICITY [J].
ALBERT, A .
NATURE, 1958, 182 (4633) :421-423
[7]   Extraction, Isolation and Characterization of Bioactive Compounds from Artemisia and Their Biological Significance: A Review [J].
Anibogwu, Rosemary ;
De Jesus, Karl ;
Pradhan, Samjhana ;
Pashikanti, Srinath ;
Mateen, Sameena ;
Sharma, Kavita .
MOLECULES, 2021, 26 (22)
[8]  
[Anonymous], 2006, WHO monograph on good agricultural and collection practices (GACP) for Artemisia annua L
[9]  
[Anonymous], 2013, J. Virol. Antivir. Res
[10]  
[Anonymous], 2020, Mateon Expands Its Covid-19 Therapeutic Program to Include Artemisinin