Combined effects of time-restricted eating and exercise on short-term blood glucose management in individuals with Type 2 Diabetes Mellitus: The TREx study, a randomised controlled trial

被引：0

作者：

Bravo-Garcia, Ana Paula ^{[1
]}

Radford, Bridget E. ^{[1
]}

Hall, Rebecca C. ^{[1
]}

Broome, Sophie C. ^{[1
]}

Tee, Nicolin ^{[1
]}

Arthur, Bronte ^{[1
]}

Janssens, Kristel ^{[1
]}

Johnston, Rich ^{[2
,3
,4
]}

Halson, Shona L. ^{[2
,3
]}

Devlin, Brooke L. ^{[5
]}

Hawley, John A. ^{[1
,6
]}

Parr, Evelyn B. ^{[1
]}

机构：

[1] Australian Catholic Univ ACU, Mary MacKillop Inst Hlth Res, Melbourne, Australia

[2] Australian Catholic Univ, Sports Performance Recovery Injury & New Technol S, Melbourne, Australia

[3] Australian Catholic Univ, Sch Behav & Hlth Sci, Brisbane, Qld, Australia

[4] Leeds Beckett Univ, Carnegie Appl Rugby Res CARR Ctr, Carnegie Sch Sport, Leeds, England

[5] Univ Queensland, Sch Human Movement & Nutr Sci, St Lucia, Qld, Australia

[6] Manchester Metropolitan Univ, Inst Sport, Dept Sport & Exercise Sci, Manchester, England

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2025年 / 222卷

关键词：

Meal timing; Exercise timing; Glucose; Insulin; Time-restricted eating; Type 2 diabetes mellitus; CARDIOVASCULAR EVENTS; GLYCEMIC CONTROL; RISK; HYPERGLYCEMIA; STATEMENT; WEIGHT; HEALTH;

D O I：

10.1016/j.diabres.2025.112081

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: Time-restricted eating (TRE) is a chrono-nutrition strategy where the daily 'eating window' is reduced to 8-10 h. We investigated the acute (14-h) effects of TRE, with and without post-meal exercise, on blood glucose and insulin concentrations in people with type 2 diabetes mellitus. Methods: Fourteen participants (5 F, 9 M; HbA1c: 7.6 +/- 1.0%) completed four conditions in this randomised crossover study: CON (eating window, 0800-2000 h), CON with exercise (CON + Ex; 0800-2000 h + 15 min walking at 60% VO(2)peak, 45 min post-meal), TRE (eating window 1000-1800 h), and TRE with exercise (TRE + Ex, 1000-1800 h + 15 min walking as per CON + Ex), with standardised meals. Venous blood samples were collected at 26-timepoints and analysed for glucose and insulin concentrations. Statistical analysis used linear mixed-effects models with P < 0.05. Results: Reducing the eating window had little effect on plasma glucose 14-h area under the curve (AUC). Exercise reduced insulin 14-h AUC (P=0.01) with no additive effect of TRE. Conclusion: Post-meal exercise lowered 14-h insulin AUC, neither 8-h TRE nor post-meal exercise altered 14-h blood glucose compared with 12-h eating window. Future work should focus on long-term effects of TRE combined with exercise for enhancing blood glucose in people with type 2 diabetes mellitus.

引用

页数：9

共 48 条

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