Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis

被引：0

作者：

Liu, Christine M. ^{[1
]}

Fischer, Jakob L. ^{[1
]}

Lee, Michelle J. ^{[1
]}

Mace, Jess C. ^{[2
]}

Kimple, Adam J. ^{[3
]}

Markarian, Karolin ^{[4
]}

Alt, Jeremiah A. ^{[5
]}

Bodner, Todd E. ^{[6
]}

Chowdhury, Naweed I. ^{[7
]}

Chung, Sei Y. ^{[8
]}

Eshaghian, Patricia H. ^{[9
]}

Gao, Yuqing A. ^{[9
]}

Getz, Anne E. ^{[10
]}

Hwang, Peter H. ^{[11
]}

Khanwalkar, Ashoke ^{[10
]}

Lee, Jivianne T. ^{[1
]}

Li, Douglas A. ^{[9
]}

Norris, Meghan ^{[3
]}

Nayak, Jayakar V. ^{[11
]}

Overdevest, Jonathan B. ^{[12
]}

Owens, Cameran ^{[10
]}

Patel, Zara M. ^{[11
]}

Pappas, Lindsay E. ^{[9
]}

Poch, Katie ^{[13
]}

Schlosser, Rodney J. ^{[14
]}

Smith, Kristine A. ^{[5
]}

Smith, Timothy L. ^{[2
]}

Soler, Zachary M. ^{[5
]}

Suh, Jeffrey D. ^{[1
]}

Turner, Grant A. ^{[2
]}

Wang, Marilene B. ^{[1
]}

Taylor-Cousar, Jennifer L. ^{[13
,15
]}

Saavedra, Milene T. ^{[13
]}

Beswick, Daniel M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Head & Neck Surg, Los Angeles, CA 90095 USA

[2] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR USA

[3] Univ North Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC USA

[4] Univ Calif Los Angeles, CTSI, David Geffen Sch Med, Los Angeles, CA USA

[5] Univ Utah, Dept Otolaryngol Head & Neck Surg, Salt Lake City, UT USA

[6] Portland State Univ, Dept Psychol, Portland, OR USA

[7] Vanderbilt Hlth, Dept Otolaryngol Head & Neck Surg, Nashville, TN USA

[8] Univ Texas Southwestern Med Ctr, Dept Otolaryngol Head & Neck Surg, Dallas, TX USA

[9] Univ Calif Los Angeles, Dept Pulm Med, Los Angeles, CA USA

[10] Univ Colorado, Dept Otolaryngol Head & Neck Surg, Aurora, CO USA

[11] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Palo Alto, CA USA

[12] Columbia Univ, Irving Med Ctr, NewYork Presbyterian, Dept Otolaryngol Head & Neck Surg, New York, NY USA

[13] Natl Jewish Hlth, Dept Med, Denver, CO USA

[14] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC USA

[15] Natl Jewish Hlth, Dept Pediat, Denver, CO USA

来源：

LARYNGOSCOPE | 2025年 / 135卷 / 07期

关键词：

CFTR modulator therapy; chronic rhinosinusitis; cystic fibrosis; elexacaftor/tezacaftor/ivacaftor; olfactory dysfunction; NUTRITIONAL-STATUS; INTERRATER AGREEMENT; NASAL ENDOSCOPY; DYSFUNCTION; SMELL; RELIABILITY; VALIDITY; SYSTEMS; IMPACT; LUND;

D O I：

10.1002/lary.32155

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives: Olfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF) and chronic rhinosinusitis (CRS). OD is associated with impaired quality of life (QOL) and dietary alterations in certain non-CF populations. This study explored relationships between OD, QOL, and modulator use in PwCF. Methods: This is a cross-sectional analysis of an ongoing multicenter, prospective study (2019-2023) investigating PwCF with comorbid CRS. Participants completed the 40-Question Smell Identification Test (SIT-40), 22-question SinoNasal Outcome Test-(SNOT-22), Questionnaire of Olfactory Disorders (QOD-NS), and Cystic Fibrosis Questionnaire-Revised (CFQ-R). Clinical and sinus CT data were collected. After stratification by SIT-40 score, data was analyzed by chi-square, Kruskal-Wallis, Spearman correlation, and logistic regression to identify factors associated with OD. Results: Of 59 participants, those with anosmia (n = 12) had worse eating-related QOL (CFQ-R eating) compared to individuals with normosmia (n = 16) and hyposmia (n = 31). Participants with anosmia had worse sinus CT scores than those with hyposmia. Although PwCF treated with highly effective modulator therapy (HEMT; n = 30) had better CT scores vs. non-HEMT individuals (n = 23), rates of OD in both groups were comparable. Higher SNOT-22 total scores were associated with increased odds of hyposmia or anosmia. In an eating-related QOD-NS subscore, those with worse CFQ-R eating had 2.38 times higher odds of having OD. Each point decrease in CFQ-R eating domain score was associated with 10% increased odds of OD. Conclusion: In PwCF, OD was associated with increased CRS severity, impaired olfactory QOL, and decreased CFQ-R eating. There were no differences in SIT-40 or QOD-NS scores based on HEMT status.

引用

页码：2476 / 2488

页数：13

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