Effect of hepatitis B vaccination on HBV-infection among school children in Yaounde; ten years after the introduction of HBV vaccine into routine Immunization Program in Cameroon

被引:1
作者
Nguwoh, Philippe Salomon [1 ,2 ,3 ,4 ,5 ]
Ngounouh, Christian Taheu [1 ,2 ,3 ,4 ,5 ]
Essomba, Rene Ghislain [1 ,6 ]
Olinga, Patrice Zanga [2 ,3 ,5 ]
Likeng, Julienne Louise Ngo [4 ,5 ,7 ]
Nguepidjo, Gilbert [2 ,3 ]
Douyong, Sandrine Chimene Tonmeu [1 ,2 ]
Tchoffo, Desire [2 ,5 ,7 ]
Nlend, Anne Esther Njom [8 ]
Assoumou, Marie Claire Okomo [1 ,6 ]
Fokam, Joseph [7 ,9 ,10 ]
机构
[1] Minist Publ Hlth, Natl Publ Hlth Lab, Yaounde, Cameroon
[2] Distant Prod House Univ, Lewes, DE USA
[3] Univ Douala, Higher Inst Hlth Profess, Fac Med & Pharmaceut Sci, Yaounde, Cameroon
[4] Univ Douala, Higher Inst Sci & Tech Appl Hlth, Fac Med & Pharmaceut Sci, Yaounde, Cameroon
[5] Univ Lisala, Fac Hlth Sci, Lisala, Mongala, DEM REP CONGO
[6] Univ Yaounde I, Fac Med & Biomed Sci, Yaounde, Cameroon
[7] Catholic Univ Cent Africa, Sch Hlth Sci, Yaounde, Cameroon
[8] Univ Douala, Higher Inst Med Technol, Fac Med & Pharmaceut Sci, Yaounde, Cameroon
[9] Univ Buea, Fac Hlth Sci, Buea, Cameroon
[10] Chantal BIYA Int Reference Ctr Res HIV AIDS preven, Yaounde, Cameroon
关键词
Effect; HBV-infection; vaccination status; children; Yaounde;
D O I
10.11604/pamj.2024.47.169.40369
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Introduction: since the introduction of the antiHBV vaccine into the Expanded Program on Immunization (EPI) in 2005 in Cameroon, vaccination coverage has reached 99.0%. This coverage would indicate an increase in the number of children immune to Hepatitis B Virus (HBV) and a decrease in susceptibility to HBV-infection. This study was conducted to evaluate the effect of the HBV vaccine on pediatric HBV-infection in Yaounde, Cameroon. Methods: this school-based cross-sectional study was conducted from February to May 2016 among 180 children from Nkomo public school. The study population was stratified into two groups: vaccinated (n=95) versus (vs) unvaccinated (n=85). Screening for HBV biomarkers was done using a rapid panel test for detection (HBsAg, HBeAg and anti-HBc) and anti HBs titer using enzyme linked immunosorbent assay (ELISA). Statistical analyses were done using SPSS v. 22 with p < 0.05 considered significant. Results: the mean age was 9.65 years. HBsAg (p=0.019) and anti-HBc (p=0.001) rates were detected in children aged >= 10 years and children aged < 10 years (95.95% [71/74]) were vaccinated vs 22.64% (24/106) for those aged >= 10 years (OR: 80.86; 95% CI: 23.36%-279.87%, p < 0.0001). According to anti-HBV vaccination status, HBsAg rate varied from [9.41% (8/85) to 1.05% (1/95), p=0.025], HBeAg rate varied from [2.35% (2/85) to 0% (0/95), p= 0.42] and anti-HBc rate ranged from [12.94% (11/85) to 2.10% (2/95), p= 0.011]. Conclusion: despite the variability of the anti-HBs titer, vaccination against HBV has a positive effect on the reduction of HBV-infection in children in tropical settings such as Cameroon.
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页数:12
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