Semi-Automated Analysis of Dome-Shaped Macula in Preterm and Full-Term Infants Using Handheld Swept-Source Optical Coherence Tomography

被引：1

作者：

Dang, Joshua N. ^{[1
]}

Wu, Jolan ^{[2
,3
]}

Zheng, Yujiao ^{[4
]}

Bunk, Jason J. ^{[3
]}

Tam, Emily K. ^{[5
]}

Lee, Karen E. ^{[6
]}

Lawson, Sumner E. ^{[7
]}

Monger, Tatiana R. ^{[2
]}

Legocki, Alex T. ^{[3
]}

Kelly, John P. ^{[2
]}

Egeolu, Obiageri ^{[2
,3
]}

Ding, Leona ^{[3
]}

Wang, Ruikang K. ^{[3
,4
]}

Tarczy-Hornoch, Kristina ^{[2
,3
]}

Cabrera, Michelle T. ^{[2
,3
]}

机构：

[1] Calif Univ Sci & Med, Sch Med, Colton, CA USA

[2] Seattle Childrens Hosp, Div Ophthalmol, Seattle, WA USA

[3] Univ Washington, Dept Ophthalmol, Seattle, WA USA

[4] Univ Washington, Dept Bioengn, Seattle, WA USA

[5] Mary Bridge Childrens Hosp, Dept Ophthalmol, Tacoma, WA USA

[6] Univ N Carolina, Dept Ophthalmol, Chapel Hill, NC USA

[7] Univ Washington, Sch Med, Seattle, WA USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2024年 / 65卷 / 12期

基金：

美国国家卫生研究院;

关键词：

dome-shaped macula (DSM); optical coherence tomography (OCT); retinopa- thy of prematurity (ROP); HIGHLY MYOPIC EYES; VISUAL-ACUITY; PREMATURITY; RETINOPATHY; FEATURES;

D O I：

10.1167/iovs.65.12.35

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE . Dome-shaped macula (DSM) is known to occur in highly myopic adults and, recently, preterm infants. This study uses investigational handheld swept-source optical coherence tomography (SS-OCT) to further characterize infantile DSM. METHODS . In this prospective, observational study, preterm infants undergoing retinopathy of prematurity screening and full-term infants within 72 hours of birth were imaged. Two trained graders assessed macular features, including DSM, subretinal fluid, and macular edema. A semi-automated program measured foveal immaturity, dome height, and diameter. RESULTS . Two hundred seventeen imaging sessions from 50 full-term and 30 preterm infants were included (46% female, preterm birth weight 1038 +/- 335 g, and gestational age 28.7 +/- 3.1 weeks). DSM occurred in 40% preterm versus 14% full-term infants (P = 0.01). Mean postmenstrual age at first DSM diagnosis was 38.4 +/- 0.0 weeks among preterm and 40.4 +/- 1.1 weeks among full-term infants (P < 0.001). Dome height and diameter measured 55.67 +/- 44.22 pm and 3583.15 +/- 1090.35 pm for preterm versus 88.37 +/- 44.73 pm and 3581.97 +/- 355.07 pm for full-term infants (P = 0.24 and P = 0.96, respectively). All 27 images (11 preterm and 7 full-term infants) with 3-dimensional analysis had round dome configuration. No other associations were seen, including macular fluid (P = 0.17). CONCLUSIONS . Infants frequently exhibit DSM without an association with macular fluid. Preterm infants were more likely than full-term infants to have DSM. Unlike DSM in children and adults, infantile DSM configuration is mostly round rather than ridge-shaped.

引用

页数：8

共 31 条

[1] Central macular thickness is correlated with gestational age at birth in prematurely born children [J].