Inflammation in Cerebral Amyloid Angiopathy-Related Transient Focal Neurological Episodes

被引：1

作者：

Sellimi, Amina ^{[1
,2
,3
]}

Panteleienko, Larysa ^{[1
]}

Mallon, Dermot ^{[4
]}

Fandler-Hofler, Simon ^{[1
,5
]}

Oliver, Rupert ^{[4
]}

Harvey, Victoria ^{[4
]}

Zandi, Michael S. ^{[6
]}

Banerjee, Gargi ^{[4
,7
]}

Werring, David J. ^{[1
,4
]}

机构：

[1] UCL Queen Sq Institue Neurol, Dept Brain Repair & Rehabil, UCL Stroke Res Ctr, London, England

[2] UClouvain, Clin Univ St Luc, Dept Neurol, Brussels, Belgium

[3] UCLouvain, Inst Neurosci, Brussels, Belgium

[4] Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Queen Sq, London, England

[5] Med Univ Graz, Dept Neurol, Graz, Austria

[6] UCL Queen Sq Inst Neurol, Dept Neuroinflammat, London, England

[7] UCL, Inst Prion Dis, MRC Prion Unit, London, England

来源：

ANNALS OF NEUROLOGY | 2025年

关键词：

HEMORRHAGE;

D O I：

10.1002/ana.27164

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transient focal neurological episodes (TFNE), often associated with convexity subarachnoid hemorrhage (cSAH), are common in cerebral amyloid angiopathy (CAA), but their pathophysiology remains incompletely understood. In six patients with unremitting TFNE, using high-resolution post-contrast magnetic resonance imaging and vessel wall imaging (VWI), we found various combinations of transient leptomeningeal, parenchymal and vessel wall enhancement; in 5 of 6 the enhancement included regions corresponding anatomically to symptoms. Three patients had resolution of TFNE and enhancement (2 with corticosteroid treatment, 1 without). Our observations suggest that inflammation might contribute to the pathophysiology of CAA-related TFNE and cSAH, with potential wider relevance for the associated high risks of recurrent ICH in CAA more generally. ANN NEUROL 2025

引用

页数：8

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