A non-contact wearable device for monitoring epidermal molecular flux

被引：0

作者：

Jaeho Shin ^{[1
]}

Joseph Woojin Song ^{[2
]}

Matthew Thomas Flavin ^{[1
]}

Seunghee Cho ^{[3
]}

Shupeng Li ^{[4
]}

Ansen Tan ^{[5
]}

Kyung Rok Pyun ^{[1
]}

Aaron G Huang ^{[6
]}

Huifeng Wang ^{[1
]}

Seongmin Jeong ^{[7
]}

Kenneth E. Madsen ^{[1
]}

Jacob Trueb ^{[3
]}

Mirae Kim ^{[4
]}

Katelynn Nguyen ^{[1
]}

Angela Yang ^{[1
]}

Yaching Hsu ^{[8
]}

Winnie Sung ^{[3
]}

Jiwon Lee ^{[4
]}

Sooyeol Phyo ^{[2
]}

Ji-Hoon Kim ^{[1
]}

Anthony Banks ^{[9
]}

Jan-Kai Chang ^{[1
]}

Amy S. Paller ^{[3
]}

Yonggang Huang ^{[4
]}

Guillermo A. Ameer ^{[1
]}

John A. Rogers ^{[10
]}

机构：

[1] Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL

[2] Center for Advanced Molecular Recognition, Korea Institute of Science and Technology, Seoul

[3] Department of Biomedical Engineering, Northwestern University, Evanston, IL

[4] Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL

[5] Chan Zuckerberg Biohub Chicago, Chicago, IL

[6] School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA

[7] Department of Mechanical Engineering, Northwestern University, Evanston, IL

[8] Wearifi Inc, Northfield, IL

[9] Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL

[10] Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL

[11] Center for Climate and Carbon Cycle Research, Korea Institute of Science and Technology, Seoul

[12] Division of Energy and Environment Technology, Korea Institute of Science and Technology, Seoul

[13] Department of Materials Science and Engineering, Korea University, Seoul

[14] Department of KHU-KIST Convergence Science and Technology, Kyung Hee University, Seoul

[15] Department of Civil Engineering, Northwestern University, Evanston, IL

[16] Department of Surgery, Northwestern University, Chicago, IL

[17] International Institute for Nanotechnology, Northwestern University, Evanston, IL

[18] Department of Materials Science and Engineering, Northwestern University, Evanston, IL

[19] Department of Dermatology, Northwestern University, Evanston, IL

[20] Department of Neurological Surgery, Northwestern University, Evanston, IL

[21] Department of Chemistry, Northwestern University, Evanston, IL

[22] Department of Chemical Engineering, Northwestern University, Evanston, IL

[23] Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL

来源：

Nature | 2025年 / 640卷 / 8058期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1038/s41586-025-08825-2

中图分类号：

学科分类号：

摘要：

Existing wearable technologies rely on physical coupling to the body to establish optical1,2, fluidic3,4, thermal5,6 and/or mechanical7,8 measurement interfaces. Here we present a class of wearable device platforms that instead relies on physical decoupling to define an enclosed chamber immediately adjacent to the skin surface. Streams of vapourized molecular substances that pass out of or into the skin alter the properties of the microclimate defined in this chamber in ways that can be precisely quantified using an integrated collection of wireless sensors. A programmable, bistable valve dynamically controls access to the surrounding environment, thereby creating a transient response that can be quantitatively related to the inward and outward fluxes of the targeted species by analysing the time-dependent readings from the sensors. The systems reported here offer unique capabilities in measuring the flux of water vapour, volatile organic compounds and carbon dioxide from various locations on the body, each with distinct relevance to clinical care and/or exposure to hazardous vapours. Studies of healing processes associated with dermal wounds in models of healthy and diabetic mice and of responses in models using infected wounds reveal characteristic flux variations that provide important insights, particularly in scenarios in which the non-contact operation of the devices avoids potential damage to fragile tissues. © The Author(s), under exclusive licence to Springer Nature Limited 2025.

引用

页码：375 / 383

页数：8

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