Investigation of the Mechanism of Pachyman against Gout Arthritis with Network Pharmacology Analysis and Verification In Vivo

被引：0

作者：

Kong, Qing-xin ^{[1
]}

Xu, Wei-ping ^{[2
]}

Fan, Cheng ^{[1
]}

Liu, Bi-Lin ^{[1
]}

Reng, Li-Ping ^{[1
]}

Ruan, Qiao ^{[1
]}

机构：

[1] Chongqing Chem Ind Vocat Coll, Coll Pharm, Chongqing 401228, Peoples R China

[2] Hosp Southwest Univ Polit Sci & Law, Coll Pharm, Chongqing 401120, Peoples R China

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2025年

关键词：

Gout; arthritis; pachyman; network pharmacology; relaxin signaling pathway; anti-inflammation; anti-fibrosis; anti-oxidation; INFLAMMATION; COLCHICINE; POLYSACCHARIDES; ANTITUMOR; RELAXIN;

D O I：

10.2174/0113862073330896241211155436

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose Pachyman, derived from Poria cocos, has been used to treat gouty arthritis (GA) for thousands of years, although its precise role and mechanisms remain unclear. Herein, we investigate the therapeutic effects of pachyman on GA and explore their underlying mechanisms.Methods Network pharmacology and experimental methods were employed to investigate the therapeutic mechanisms of pachyman against GA. The protein-protein interaction network of shared targets between pachyman and gout was constructed. Furthermore, we elucidated the functions and mechanisms of pachyman against GA. Subsequently, we validated the predicted mechanisms from an experiment on rats.Results The treatment of GA with pachyman primarily related to tumor necrosis factor (TNF), matrix metalloproteinases (MMP), and relaxation factor signaling pathways. In the experimental validation, pachyman were found to regulate the expression of IL-1 beta, TNF-alpha, TGF-beta, superoxide dismutase, and glutathione peroxidase of hyperuricemic rats.Conclusion These collective findings suggest that pachyman holds promise as an alternative treatment for GA.

引用

页数：8