Multiomic analyses reveal new targets of polycomb repressor complex 2 in Schwann lineage cells and malignant peripheral nerve sheath tumors

被引：1

作者：

Bhunia, Minu M. ^{[1
,2
]}

Stehn, Christopher M. ^{[1
,2
]}

Jubenville, Tyler A. ^{[1
]}

Novacek, Ethan L. ^{[1
]}

Larsson, Alex T. ^{[1
]}

Madala, Mahathi ^{[1
]}

Suppiah, Suganth ^{[3
,4
]}

Velez-Reyes, German L. ^{[1
]}

Williams, Kyle B. ^{[1
]}

Sokolowski, Mark ^{[1
]}

Williams, Rory L. ^{[1
]}

Finnerty, Samuel J. ^{[1
,2
]}

Temiz, Nuri A. ^{[1
]}

Caride, Ariel ^{[5
]}

Bhagwate, Aditya, V ^{[6
]}

Nagaraj, Nagaswaroop K. ^{[6
]}

Lee, Jeong-Heon ^{[5
]}

Ordog, Tamas ^{[5
]}

Zadeh, Gelareh ^{[3
,4
]}

Largaespada, David A. ^{[1
,2
]}

机构：

[1] Univ Minnesota, Masonic Canc Ctr, Dept Pediat, Minneapolis, MN 55455 USA

[2] Univ Minnesota Twin Cities, Dept Genet Cell Biol & Dev, Minneapolis, MN USA

[3] Univ Toronto, Univ Hlth Network, Div Neurosurg, Toronto, ON, Canada

[4] Princess Margaret Canc Ctr, MacFeeters Hamilton Ctr Neurooncol, Toronto, ON, Canada

[5] Mayo Clin, Epigen Program, Ctr Individualized Med, Epigen Dev Lab, Rochester, MN USA

[6] Mayo Clin, Dept Biomed Stat & Informat, Rochester, MN USA

来源：

NEURO-ONCOLOGY ADVANCES | 2024年 / 6卷 / 01期

关键词：

MPNST; NF1; nirogacestat; notch signaling; PRC2; GAMMA-SECRETASE INHIBITOR; NOTCH; CANCER; PATHWAY; MUTATION; SUZ12; PRC2;

D O I：

10.1093/noajnl/vdae188

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant peripheral nerve sheath tumors (MPNSTs) are cancers that affect the protective covering of nerves. In these cancers, a protein complex called PRC2, which is important for normal cell behavior, is often absent. The authors of this study wanted to figure out how the loss of the PRC2 may cause tumors to grow. To do this, they studied normal cells that cover nerves that lack PRC2 and compared them with MPNSTs. Their results showed that losing PRC2 changes many genes, including some that are linked to cancer development. Two important pathways, called Notch and SHH, were found to play a key role. Blocking these pathways helped slow down tumor growth.

引用

页数：16

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