Methylated cell-free DNA as a novel biomarker in Alzheimer's disease

被引：1

作者：

Zhen, Mengyang ^{[1
,2
,3
]}

Dang, Miao ^{[2
,3
]}

Cao, Zexiang ^{[2
,3
]}

Xia, Xiaoying ^{[2
,3
]}

Peng, Fan ^{[2
,3
]}

Wang, Siyuan ^{[2
,3
]}

Liu, Yang ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Clin Diag, Xian, Peoples R China

[2] Fourth Mil Med Univ, State Key Lab Holist Integrat Management Gastroint, Xian, Peoples R China

[3] Fourth Mil Med Univ, Dept Physiol & Pathophysiol, Xian, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2025年 / 566卷

关键词：

Alzheimer's disease; Biomarker; Cell-free DNA; Methylation;

D O I：

10.1016/j.cca.2024.120069

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Due to an aging population, Alzheimer's disease (AD), a neurodegenerative disorder, has affected more than 40 million people worldwide, a figure predicted to significantly increase in the coming decades. Despite much effort to understand AD pathogenesis, effective diagnosis and treatment remain a challenge. However, the development of liquid biopsy including the analysis of cell-free DNA (cfDNA) and methylation thereof has provided an alternative source of investigation to further explore the pathophysiology of AD. Herein, we discuss the research progress to date and highlight clinical applications of methylated cfDNA in AD.

引用

页数：4

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