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Asymmetric Hydrogenation of Polysubstituted Isoquinolines with Chiral Boranes
被引:0
作者:
Zou, Fuqu
[1
,2
]
Feng, Xiangqing
[1
,2
]
Du, Haifeng
[1
,2
]
机构:
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金:
国家重点研发计划;
中国国家自然科学基金;
关键词:
FRUSTRATED LEWIS PAIRS;
IRIDIUM-CATALYZED HYDROGENATION;
METAL-FREE HYDROGENATIONS;
ENANTIOSELECTIVE HYDROGENATION;
CHEMISTRY;
HETEROCYCLES;
QUINOLINES;
PROGRESS;
BEARING;
ROUTE;
D O I:
10.1021/acs.orglett.5c00272
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
This paper describes an asymmetric hydrogenation of 1,3-disubstituted isoquinolines catalyzed by chiral borane derived from chiral alkene, giving the desired cis-products in high yields with up to 96% ee. In particular, the asymmetric hydrogenation of challenging 1,3,4-trisubstituted isoquinolines could proceed smoothly to afford the corresponding products in high yields with moderate ee's for the first time.
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页码:2186 / 2190
页数:5
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