Asymmetric Hydrogenation of Polysubstituted Isoquinolines with Chiral Boranes

被引:0
作者
Zou, Fuqu [1 ,2 ]
Feng, Xiangqing [1 ,2 ]
Du, Haifeng [1 ,2 ]
机构
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
FRUSTRATED LEWIS PAIRS; IRIDIUM-CATALYZED HYDROGENATION; METAL-FREE HYDROGENATIONS; ENANTIOSELECTIVE HYDROGENATION; CHEMISTRY; HETEROCYCLES; QUINOLINES; PROGRESS; BEARING; ROUTE;
D O I
10.1021/acs.orglett.5c00272
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This paper describes an asymmetric hydrogenation of 1,3-disubstituted isoquinolines catalyzed by chiral borane derived from chiral alkene, giving the desired cis-products in high yields with up to 96% ee. In particular, the asymmetric hydrogenation of challenging 1,3,4-trisubstituted isoquinolines could proceed smoothly to afford the corresponding products in high yields with moderate ee's for the first time.
引用
收藏
页码:2186 / 2190
页数:5
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