Asymmetric Hydrogenation of Polysubstituted Isoquinolines with Chiral Boranes

被引：0

作者：

Zou, Fuqu ^{[1
,2
]}

Feng, Xiangqing ^{[1
,2
]}

Du, Haifeng ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 09期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

FRUSTRATED LEWIS PAIRS; IRIDIUM-CATALYZED HYDROGENATION; METAL-FREE HYDROGENATIONS; ENANTIOSELECTIVE HYDROGENATION; CHEMISTRY; HETEROCYCLES; QUINOLINES; PROGRESS; BEARING; ROUTE;

D O I：

10.1021/acs.orglett.5c00272

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes an asymmetric hydrogenation of 1,3-disubstituted isoquinolines catalyzed by chiral borane derived from chiral alkene, giving the desired cis-products in high yields with up to 96% ee. In particular, the asymmetric hydrogenation of challenging 1,3,4-trisubstituted isoquinolines could proceed smoothly to afford the corresponding products in high yields with moderate ee's for the first time.

引用

页码：2186 / 2190

页数：5

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