Hyaluronic Acid: A Comprehensive Review of Its Osteogenic Potential and Diverse Biomedical Applications

被引：0
作者：
Saranya Srinivasan [1 ]
Ashwathi Vijayalekha [1 ]
Sureshkumar Anandasadagopan [2 ]
Ashok Kumar Pandurangan [1 ]
机构：
[1] School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, Vandalur
[2] Biochemistry and Biotechnology Laboratory, CSIR-Central Leather Research Institute Adyar, Chennai
来源：
Current Pharmacology Reports | / 11卷 / 1期
关键词：
Biomedical applications; Bone tissue engineering; Hyaluronic acid; Osteogenic potential;
D O I：
10.1007/s40495-025-00408-z
中图分类号：
学科分类号：
摘要：
Purpose of Review: Bone defects often heal naturally, but larger defects require intervention through Bone Tissue Engineering (BTE). This review highlights Hyaluronic acid (HA), a biopolymer essential to the extracellular matrix (ECM), emphasizing its unique properties and role in enhancing osteogenesis in HA-based biomaterials. Recent Findings: Hyaluronic acid plays crucial roles in cell proliferation, joint lubrication, and wound healing. Studies demonstrate that HA-based biomaterials, when combined with other biopolymers or bioactive compounds, exhibit improved mechanical and biomedical properties. HA’s viscoelastic and shear-thinning rheological characteristics enhance its functionality, while its mechanical properties ensure structural stability. Additionally, HA acts as a carrier for osteoconductive compounds, significantly boosting osteogenic and osteointegration outcomes. Summary: Optimizing HA’s application in BTE elucidates the understanding of its rheological, mechanical, and biological properties. This review evaluates HA’s foundational role in bone regeneration and prior studies incorporating bioactive molecules to enhance its osteogenic potential. Clinical trial number: Not applicable. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2025.
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