Difluoroenoxysilanes in Catalytic Asymmetric Allylic Alkylation

被引：0

作者：

Mondal, Subhajit ^{[1
]}

Das, Priyotosh ^{[1
]}

Mukherjee, Santanu ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, India

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 50期

关键词：

MUKAIYAMA-MANNICH REACTION; ENANTIOSELECTIVE ALLYLATION; ORGANOFLUORINE CHEMISTRY; ATOM ECONOMY; FLUORINE; SUBSTITUTION; INHIBITORS; ANALOGS; ETHERS; ALCOHOLS;

D O I：

10.1021/acs.orglett.4c04279

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An allylic substitution with difluoroenoxysilanes as the nucleophile is accomplished for the enantioselective synthesis of alpha-allylic alpha,alpha-difluoroketones. With racemic branched allylic alcohols as the easily accessible allylic electrophile, this branched-selective and enantioconvergent allylic alkylation reaction is catalyzed by an Ir(I)/(P,olefin) complex and overcomes the low nucleophilicity of difluoroenoxysilanes to furnish beta-chiral alpha,alpha-difluoroketones in moderate to good yields with high enantioselectivity (up to >99.9:0.1 er).

引用

页码：11073 / 11079

页数：7

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