Lung cancer screening in never smokers

被引：2

作者：

Lai, Gillianne G. Y. ^{[1
,2
]}

Tan, Daniel S. W. ^{[1
,2
,3
]}

机构：

[1] Natl Canc Ctr Singapore, Div Med Oncol, Singapore, Singapore

[2] Natl Canc Ctr Singapore, Duke NUS Med Sch, Singapore, Singapore

[3] Natl Canc Ctr Singapore, Div Clin Trials & Epidemiol Sci, Singapore, Singapore

来源：

CURRENT OPINION IN ONCOLOGY | 2025年 / 37卷 / 01期

关键词：

lung cancer; nonsmokers; screening; tomography; COMPUTED-TOMOGRAPHY; RISK; CT; SMOKING; EXPOSURE; ASIA; ADENOCARCINOMA; SURVIVAL; DISEASE; PROFILE;

D O I：

10.1097/CCO.0000000000001099

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of reviewLow-dose computed tomography (LDCT) lung cancer screening has been established in smokers, but its role in never smokers remains unclear. The differences in lung cancer biology between smokers and nonsmokers highlight the importance of a discriminated approach. This overview focuses on the emerging data and implementation challenges for LDCT screening in nonsmokers.Recent findingsThe first LDCT screening study in nonsmokers enriched with risk factors demonstrated a lung cancer detection rate double that of the phase 3 trials in smokers. The relative risk of lung cancer detected by LDCT has also been found to be similar amongst female never smokers and male ever smokers in Asia. Majority of lung cancers detected through LDCT screening are stage 0/1, leading to concerns of overdiagnosis. Risk prediction models to enhance individual selection and nodule management could be useful to enhance the utility of LDCT screening in never smokers.SummaryWith appropriate risk stratification, LDCT screening in never smokers may attain similar efficacy as compared to smokers. A global effort is needed to generate evidence surrounding optimal screening strategies, as well as health and economic benefits to determine the suitability of widespread implementation.

引用

页码：95 / 104

页数：10

共 66 条

[1] Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening [J].

Aberle, Denise R. ;

Adams, Amanda M. ;

Berg, Christine D. ;

Black, William C. ;

Clapp, Jonathan D. ;

Fagerstrom, Richard M. ;

Gareen, Ilana F. ;

Gatsonis, Constantine ;

Marcus, Pamela M. ;

Sicks, JoRean D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) :395-409

[2] The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations [J].

Ahn, Myung-Ju ;

Won, Hong-Hee ;

Lee, Jeeyun ;

Lee, Seung-Tae ;

Sun, Jong-Mu ;

Park, Yeon Hee ;

Ahn, Jin Seok ;

Kwon, O. Jung ;

Kim, Hojoong ;

Shim, Young Mog ;

Kim, Jhingook ;

Kim, Kwhanmien ;

Kim, Yeul Hong ;

Park, Jae Yong ;

Kim, Jong-Won ;

Park, Keunchil .

HUMAN GENETICS, 2012, 131 (03) :365-372

[3] Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].

Bray, Freddie ;

Laversanne, Mathieu ;

Sung, Hyuna ;

Ferlay, Jacques ;

Siegel, Rebecca L. ;

Soerjomataram, Isabelle ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2024, 74 (03) :229-263

[4] Malignant Nodules Detected on Lung Cancer Screening CT: Yield of Short-Term Follow-Up CT in Showing Nodule Growth [J].

Byrne, Suzanne C. ;

Hammer, Mark M. .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2022, 219 (05) :735-741

[5] Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study [J].

Chang, Gee-Chen ;

Chiu, Chao-Hua ;

Yu, Chong-Jen ;

Chang, Yeun-Chung ;

Chang, Ya-Hsuan ;

Hsu, Kuo-Hsuan ;

Wu, Yu-Chung ;

Chen, Chih-Yi ;

Hsu, Hsian-He ;

Wu, Ming-Ting ;

Yang, Cheng-Ta ;

Chong, Inn-Wen ;

Lin, Yu-Ching ;

Hsia, Te-Chun ;

Lin, Meng-Chih ;

Su, Wu-Chou ;

Lin, Chih-Bin ;

Lee, Kang-Yun ;

Wei, Yu-Feng ;

Lan, Gong-Yau ;

Chan, Wing P. ;

Wang, Kao-Lun ;

Wu, Mei-Han ;

Tsai, Hao-Hung ;

Chian, Chih-Feng ;

Lai, Ruay-Sheng ;

Shih, Jin-Yuan ;

Wang, Chi-Liang ;

Hsu, Jui-Sheng ;

Chen, Kun-Chieh ;

Chen, Chun-Ku ;

Hsia, Jiun-Yi ;

Peng, Chung-Kan ;

Tang, En-Kuei ;

Hsu, Chia-Lin ;

Chou, Teh-Ying ;

Shen, Wei-Chih ;

Tsai, Ying-Huang ;

Tsai, Chun-Ming ;

Chen, Yuh-Min ;

Lee, Yu-Chin ;

Chen, Hsuan-Yu ;

Yu, Sung-Liang ;

Chen, Chien-Jen ;

Wan, Yung-Liang ;

Hsiung, Chao Agnes ;

Yang, Pan-Chyr .

LANCET RESPIRATORY MEDICINE, 2024, 12 (02) :141-152

[6] Deep learning predicts cardiovascular disease risks from lung cancer screening low dose computed tomography [J].

Chao, Hanqing ;

Shan, Hongming ;

Homayounieh, Fatemeh ;

Singh, Ramandeep ;

Khera, Ruhani Doda ;

Guo, Hengtao ;

Su, Timothy ;

Wang, Ge ;

Kalra, Mannudeep K. ;

Yan, Pingkun .

NATURE COMMUNICATIONS, 2021, 12 (01)

[7] Genomic and immune profiling of pre-invasive lung adenocarcinoma [J].

Chen, Haiquan ;

Carrot-Zhang, Jian ;

Zhao, Yue ;

Hu, Haichuan ;

Freeman, Samuel S. ;

Yu, Su ;

Ha, Gavin ;

Taylor, Alison M. ;

Berger, Ashton C. ;

Westlake, Lindsay ;

Zheng, Yuanting ;

Zhang, Jiyang ;

Ramachandran, Aruna ;

Zheng, Qiang ;

Pan, Yunjian ;

Zheng, Difan ;

Zheng, Shanbo ;

Cheng, Chao ;

Kuang, Muyu ;

Zhou, Xiaoyan ;

Zhang, Yang ;

Li, Hang ;

Ye, Ting ;

Ma, Yuan ;

Gao, Zhendong ;

Tao, Xiaoting ;

Han, Han ;

Shang, Jun ;

Yu, Ying ;

Bao, Ding ;

Huang, Yechao ;

Li, Xiangnan ;

Zhang, Yawei ;

Xiang, Jiaqing ;

Sun, Yihua ;

Li, Yuan ;

Cherniack, Andrew D. ;

Campbell, Joshua D. ;

Shi, Leming ;

Meyerson, Matthew .

NATURE COMMUNICATIONS, 2019, 10 (1)

[8] R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability [J].

Chen, Hsuan-Yu ;

Yu, Sung-Liang ;

Ho, Bing-Ching ;

Su, Kang-Yi ;

Hsu, Yi-Chiung ;

Chang, Chi-Sheng ;

Li, Yu-Cheng ;

Yang, Shi-Yi ;

Hsu, Pin-Yen ;

Ho, Hao ;

Chang, Ya-Hsuan ;

Chen, Chih-Yi ;

Yang, Hwai-I ;

Hsu, Chung-Ping ;

Yang, Tsung-Ying ;

Chen, Kun-Chieh ;

Hsu, Kuo-Hsuan ;

Tseng, Jeng-Sen ;

Hsia, Jiun-Yi ;

Chuang, Cheng-Yen ;

Yuan, Shinsheng ;

Lee, Mei-Hsuan ;

Liu, Chia-Hsin ;

Wu, Guan-I ;

Hsiung, Chao A. ;

Chen, Yuh-Min ;

Wang, Chih-Liang ;

Huang, Ming-Shyan ;

Yu, Chong-Jen ;

Chen, Kuan-Yu ;

Tsai, Ying-Huang ;

Su, Wu-Chou ;

Chen, Huei-Wen ;

Chen, Jeremy J. W. ;

Chen, Chien-Jen ;

Chang, Gee-Chen ;

Yang, Pan-Chyr ;

Li, Ker-Chau .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (20) :2303-U128

[9] Genomic landscape of lung adenocarcinoma in East Asians [J].

Chen, Jianbin ;

Yang, Hechuan ;

Teo, Audrey Su Min ;

Amer, Lidyana Bte ;

Sherbaf, Faranak Ghazi ;

Tan, Chu Quan ;

Alvarez, Jacob Josiah Santiago ;

Lu, Bingxin ;

Lim, Jia Qi ;

Takano, Angela ;

Nahar, Rahul ;

Lee, Yin Yeng ;

Phual, Cheryl Zi Jin ;

Chua, Khi Pin ;

Suteja, Lisda ;

Chen, Pauline Jieqi ;

Chang, Mei Mei ;

Koh, Tina Puay Theng ;

Ong, Boon-Hean ;

Anantham, Devanand ;

Hsu, Anne Ann Ling ;

Gogna, Apoorva ;

Too, Chow Wei ;

Aung, Zaw Win ;

Lee, Yi Fei ;

Wang, Lanying ;

Lim, Tony Kiat Hon ;

Wilm, Andreas ;

Choi, Poh Sum ;

Ng, Poh Yong ;

Toh, Chee Keong ;

Lim, Wan-Teck ;

Ma, Siming ;

Lim, Bing ;

Liu, Jin ;

Tam, Wai Leong ;

Skanderup, Anders Jacobsen ;

Yeong, Joe Poh Sheng ;

Tan, Eng-Huat ;

Creasy, Caretha L. ;

Tan, Daniel Shao Weng ;

Hillmer, Axel M. ;

Zhai, Weiwei .

NATURE GENETICS, 2020, 52 (02) :177-+

[10] Multiomics Analysis Reveals Distinct Immunogenomic Features of Lung Cancer with Ground-Glass Opacity [J].

Chen, Kezhong ;

Bai, Jing ;

Reuben, Alexandre ;

Zhao, Heng ;

Kang, Guannan ;

Zhang, Chunliu ;

Qi, Qingyi ;

Xu, Yaping ;

Hubert, Shawna ;

Chang, Lianpeng ;

Guan, Yanfang ;

Feng, Lin ;

Zhang, Kai ;

Zhang, Kaitai ;

Yi, Xin ;

Xia, Xuefeng ;

Cheng, Shujun ;

Yang, Fan ;

Zhang, Jianjun ;

Wang, Jun .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 204 (10) :1180-1191

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