Gut-liver axis in liver disease: From basic science to clinical treatment (Review)

被引：5
作者：
Wang, Jianpeng [1 ,2 ]
Wang, Xinyi [3 ]
Zhuo, Enba [4 ]
Chen, Bangjie [5 ]
Chan, Shixin [1 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Clin Med Coll 1, Dept Clin Med, Hefei 230032, Anhui, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Hefei 230032, Anhui, Peoples R China
[4] Anhui Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Hefei 230032, Anhui, Peoples R China
[5] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei 230032, Anhui, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2025年 / 31卷 / 01期
关键词：
gut-liver axis; liver disease; gut microbiota; clinical treatment; FECAL MICROBIOTA TRANSPLANTATION; INTESTINAL BARRIER FUNCTION; BACTERIAL TRANSLOCATION; ENERGY-EXPENDITURE; BILE-ACID; INFLAMMATION; CIRRHOSIS; DIAGNOSIS; CELLS; PERMEABILITY;
D O I：
10.3892/mmr.2024.13375
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Incidence of a number of liver diseases has increased. Gut microbiota serves a role in the pathogenesis of hepatitis, cirrhosis and liver cancer. Gut microbiota is considered 'a new virtual metabolic organ'. The interaction between the gut microbiota and liver is termed the gut-liver axis. The gut-liver axis provides a novel research direction for mechanism of liver disease development. The present review discusses the role of the gut-liver axis and how this can be targeted by novel treatments for common liver diseases.
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页数：15
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