Antiphospholipid Antibodies and COVID-19: A Systematic Review of Clinical Implications

被引：0

作者：

Sabaghian, Tahereh ^{[1
]}

Kharazmi, Amir Behnam ^{[2
]}

Omidi, Fatemeh ^{[3
]}

Hajikhani, Bahareh ^{[4
]}

Tehrani, Shabnam ^{[4
]}

Mardani, Sayna ^{[4
]}

Bonjar, Amir Hashem Shahidi ^{[4
]}

Centis, Rosella ^{[5
]}

D'Ambrosio, Lia ^{[6
]}

Sotgiu, Giovanni ^{[7
]}

Fabio, Angeli ^{[8
,9
]}

Nasiri, Mohammad Javad ^{[4
]}

Migliori, Giovanni Battista ^{[5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Imam Hossein Educ Hosp, Clin Res Dev Ctr, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Imam Hossein Med Ctr, Sch Med, Dept Internal Med, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Imam Hossein Hosp, Dept Cardiol, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Sch Med, Dept Microbiol, Tehran, Iran

[5] Ist Clin Sci Maugeri IRCCS, Serv Epidemiol Clin Malattie Respiratorie, Tradate, Italy

[6] Publ Hlth Consulting Grp, Lugano, Switzerland

[7] Univ Sassari, Dept Med Surg & Pharm, Clin Epidemiol & Med Stat Unit, Sassari, Italy

[8] IRCCS, Maugeri Care & Res Inst, Dept Med & Cardiopulm Rehabil, Tradate, Italy

[9] Univ Insubria, Dept Med & Technol Innovat DiMIT, Varese, Italy

来源：

IMMUNITY INFLAMMATION AND DISEASE | 2025年 / 13卷 / 02期

关键词：

antiphospholipid antibodies; COVID-19; SARS-CoV-2; systematic review; thrombosis; DISEASE; COMPLICATIONS; INFECTION; PNEUMONIA; RISK;

D O I：

10.1002/iid3.70134

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IntroductionAs the COVID-19 pandemic transitions, understanding the intricate dynamics of the disease becomes paramount. This systematic review explores the role of antiphospholipid antibodies in COVID-19, focusing on their potential clinical implications.MethodsThis systematic review, following PRISMA guidelines, assesses studies exploring the link between antiphospholipid antibodies and COVID-19. PubMed/Medline, Embase, and Scopus were searched for relevant studies published up to December 22, 2024. Inclusion criteria comprised studies involving patients diagnosed with COVID-19 and reporting on the presence of antiphospholipid antibodies. The risk of bias in individual studies was evaluated using the Joanna Briggs Institute appraisal tool.ResultsOur Study includes 59 records involving a total of 28,489 COVID-19 patients. Antiphospholipid antibodies were tested in 14,498 COVID-19 patients. It was observed that 50.84% of patients tested positive for antiphospholipid antibodies. Various types of antiphospholipid antibodies, including Anticardiolipin, Anti beta2 glycoproteins, and Lupus anticoagulant antibody, displayed prevalence rates in the patients with thrombosis. The overall frequency of antiphospholipid antibodies in thrombosis patients was 38.55%.ConclusionThe presence of antiphospholipid antibodies in a significant proportion of COVID-19 patients underscores the need for a detailed investigation into their role in thrombotic events. Our study highlights potential avenues for targeted interventions. However, the evolving nature of COVID-19 necessitates continued research efforts to clarify clinical implications and optimize management strategies in this complex landscape of thrombosis and immunology. The review reveals some limitations, such as variability in study designs and demographics and inherent differences in methodologies among included studies. Future studies should address these limitations with standardized methodologies for more conclusive findings.

引用

页数：10

共 79 条

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