Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms

被引：0
作者：
Deng, Zhijiang [1 ,2 ,3 ]
Li, Jieming [1 ,2 ,3 ]
Zhu, Pengbo [1 ,2 ,4 ]
Wang, Jie [1 ,2 ,3 ]
Kong, Yuanfang [2 ,3 ,4 ]
Hu, Yulong [1 ,2 ,3 ]
Cai, Juntao [1 ,2 ,3 ]
Dong, Chunhong [1 ,2 ,3 ]
机构：
[1] Henan Univ Chinese Med, Tradit Chinese Med Zhong Jing Sch, Zhengzhou 450046, Peoples R China
[2] Henan Polysaccharide Res Ctr, Zhengzhou 450046, Peoples R China
[3] Henan Key Lab Chinese Med Polysaccharides & Drugs, Zhengzhou 450046, Peoples R China
[4] Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China
来源：
BIOMOLECULES | 2025年 / 15卷 / 02期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
quinazolinones; catalytic synthesis; anticancer; mechanisms; 4(3H)-QUINAZOLINONE DERIVATIVES; BIOLOGICAL EVALUATION; TUBULIN POLYMERIZATION; OXIDATIVE SYNTHESIS; ANTITUMOR-ACTIVITY; EGFR INHIBITORS; MITOTIC ARREST; CELL-DEATH; APOPTOSIS; DESIGN;
D O I：
10.3390/biom15020210
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Quinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs. Given the rising cancer incidence, there is a critical need for new anticancer agents, and quinazolinones show promising potential in this domain. The present review focuses on novel advances in the synthesis of these important scaffolds and other medicinal aspects involving drug design, the structure-activity relationship, and action mechanisms of quinazoline and quinazolinone derivatives, to help in the development of new quinazoline and quinazolinone derivatives.
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页数：37
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  • [1] New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities
    Abbas, Samir Y.
    El-Bayouki, Khairy A. M.
    Basyouni, Wahid M.
    Mostafa, Eslam A.
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (02) : 571 - 582
  • [2] Discovery of New Immunomodulatory Anticancer Thalidomide Analogs: Design, Synthesis, Biological Evaluation and In Silico Studies
    Abdallah, Abdallah E.
    Eissa, Ibrahim H.
    Mehany, Ahmed B. M.
    Celik, Ismail
    Sakr, Helmy
    Metwaly, K. H.
    El-Adl, Khaled
    El-Zahabi, Mohamed Ayman
    [J]. CHEMISTRY & BIODIVERSITY, 2025, 22 (03)
  • [3] Immunomodulatory quinazoline-based thalidomide analogs: Design, synthesis, apoptosis and anticancer evaluations
    Abdallah, Abdallah E.
    Eissa, Ibrahim H.
    Mehany, Ahmed B. M.
    Sakr, Helmy
    Atwa, Ahmed
    El-Adl, Khaled
    El-Zahabi, Mohamed Ayman
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2023, 1281
  • [4] Synthesis and Biological Evaluation of a Novel Series of 6,8-Dibromo-4(3H)quinazolinone Derivatives as Anticancer Agents
    Ahmed, Marwa F.
    Youns, Mahmoud
    [J]. ARCHIV DER PHARMAZIE, 2013, 346 (08) : 610 - 617
  • [5] Some new quinazolin-4(3H)-one derivatives, synthesis and antitumor activity
    Alafeefy, Ahmed Mahmoud
    [J]. JOURNAL OF SAUDI CHEMICAL SOCIETY, 2011, 15 (04) : 337 - 343
  • [6] Discovery of Benzo[g]quinazolin benzenesulfonamide derivatives as dual EGFR/HER2 inhibitors
    Alsaid, Mansour S.
    Al-Mishari, Abdullah A.
    Soliman, Aiten M.
    Ragab, Fatma A.
    Ghorab, Mostafa M.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 141 : 84 - 91
  • [7] Recent Advances in PI3 Kinase Inhibitors: Anticancer Activities and Structure-Activity Relationships
    Asati, Vivek
    Anant, Arjun
    Mahapatra, Debarshi Kar
    Bharti, Sanjay Kumar
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2022, 22 (16) : 2146 - 2165
  • [8] Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives
    Asif, Mohammad
    [J]. INTERNATIONAL JOURNAL OF MEDICINAL CHEMISTRY, 2014, 2014
  • [9] Novel quinazolinone derivatives as anticancer agents: Design, synthesis, biological evaluation and computational studies
    Ataollahi, Elaheh
    Behrouz, Marzieh
    Mardaneh, Pegah
    Emami, Mina
    Zare, Somayeh
    Zafarian, Hamidreza
    Khabnadideh, Soghra
    Emami, Leila
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2024, 1295
  • [10] Exceedingly Fast, Direct Access to Dihydroisoquinolino[1,2-b]quinazolinones through a Ruthenium(II)-Catalyzed Redox-Neutral C-H Allylation/Hydroamination Cascade
    Bairy, Gurupada
    Das, Suvankar
    Begam, Rhasina Mamataj
    Jana, Ranjan
    [J]. ORGANIC LETTERS, 2018, 20 (22) : 7107 - 7112
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