Cortisol and 10-Year Cognitive Decline in Older People From the General Population

被引：0

作者：

Amendola, Simone ^{[1
,2
]}

Ouanes, Sami ^{[3
,4
]}

Zullo, Leonardo ^{[5
]}

Rabl, Miriam ^{[1
,2
]}

Pistis, Giorgio ^{[6
,7
]}

Castelao, Enrique ^{[6
,7
]}

Marques-Vidal, Pedro ^{[7
,8
]}

Vaucher, Julien ^{[7
,9
,10
,11
]}

von Gunten, Armin ^{[3
]}

Preisig, Martin ^{[5
]}

Popp, Julius ^{[1
,2
,3
]}

机构：

[1] Psychiat Univ Hosp Zurich, Dept Adult Psychiat & Psychotherapy, Zurich, Switzerland

[2] Univ Zurich, Zurich, Switzerland

[3] Univ Hosp Lausanne, Dept Psychiat, Serv Old Age Psychiat, Lausanne, Switzerland

[4] MindWell Kuwait, Kuwait, Kuwait

[5] Lausanne Univ Hosp, Dept Psychiat, Lausanne, Switzerland

[6] Lausanne Univ Hosp, Psychiat Epidemiol & Psychopathol Res Ctr, Dept Psychiat, Lausanne, Switzerland

[7] Univ Lausanne, Lausanne, Switzerland

[8] Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland

[9] Lausanne Univ Hosp, Univ Lausanne, Serv Internal Med, Lausanne, Switzerland

[10] Fribourg Hosp, Serv Internal Med, Fribourg, Switzerland

[11] Univ Fribourg, Fribourg, Switzerland

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2025年 / 32卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

cognition; cognitive decline; CoLaus|PsyCoLaus; cortisol; dementia; HPA axis; MENTAL-STATE-EXAMINATION; ALZHEIMERS-DISEASE; SALIVARY CORTISOL; PERFORMANCE; DEMENTIA; ASSOCIATION; STRESS;

D O I：

10.1111/ene.70056

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The present study examined bidirectional effects between salivary cortisol and cognitive functioning over time. Furthermore, the role of the APOE-epsilon 4 allele as a moderator of the associations was investigated. Methods: Using a prospective population-based study, we analyzed data from 752 older adults followed up over 10 years. A random-intercept Cross-Lagged Panel Model was applied to each combination of one cortisol measure (at waking time, 30 min after waking, 11 am, 8 pm, cortisol awakening response, total daily output, and diurnal slope) and one cognitive measure (primary outcome: Clinical Dementia Rating Scale sum of boxes score, CDR-SB; secondary outcome: Mini-Mental State Examination) resulting in 14 (7 x 2) models. Results: Between-person effects pointed out that a higher cortisol level at 11 am was associated with increased CDR-SB scores, and a higher cortisol awakening response was associated with decreased CDR-SB scores. Within-person effects indicated that cortisol levels at 11 am and 8 pm, and total daily cortisol output were associated with subsequent lower CDR-SB scores. The APOE-epsilon 4 allele did not moderate the relationship between cortisol and cognitive functioning. Conclusions: Our findings revealed within-person associations between higher cortisol levels and better cognitive functioning at the subsequent follow-up, suggesting cortisol protective effects for cognitive decline.

引用

页数：13

共 58 条

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