Critical analysis of hot topics in diabetic nephropathy related experimental research: A bibliometric analysis from 2018 to 2024

Background: Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and a leading cause of end- stage renal disease worldwide. Understanding trends in experimental research on DN is crucial for advancing knowledge and clinical management. Objective: This study aimed to explore current trends in DN related experimental research, utilizing CiteSpace, VOSviewer, and Bibliometrix to identify key contributors, influential countries, and noteworthy topics. The objective was to provide valuable insights for healthcare professionals and researchers in the field. Methods: Relevant publications from the Web of Science Core Collection Science Citation Index Expanded were retrieved for the period between 2018 and 2024. CiteSpace, VOSviewer, and Bibliometrix were employed for data analysis, including identifying top authors, institutions, countries, keywords, co-cited authors, journals, references, and research trends. Results: A total of 1501 relevant articles were included in the study. DN related experimental research exhibited an upward trend, reaching its peak in 2023. Key contributors such as Kretzler Matthias, Li Ping, and Rossing Peter emerged. China, the United States and Japan have the most publications. Keyword analysis revealed "activated protein kinase" as the most central keyword, while "diabetic nephropathy" had the highest citation rate. Recent focus shifted towards keywords like "Traditional Chinese Medicine" and "molecular docking." Conclusion: This bibliometric analysis provides insights into trends in experimental research on DN from 2018 to 2024. Notable contributors and influential countries were identified, emphasizing global collaboration. Key topics demonstrate diverse approaches and emerging trends, supporting informed decision-making and innovation in combatting DN and enhancing patient outcomes.