First insight of the genome-wide association study and genomic prediction into enteritis disease (Vibrio harveyi) resistance trait in the lined seahorse (Hippocampus erectus)

被引:0
作者
Li, Siping [1 ,2 ]
Liu, Xin [1 ,2 ]
Shen, Fengyuan [1 ,2 ]
Lin, Tingting [1 ,2 ]
Zhang, Dong [1 ,2 ]
机构
[1] Minist Agr & Rural Affairs, Key Lab Inland Saline Alkaline Aquaculture, Shanghai, Peoples R China
[2] Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
the lined seahorse; enteritis disease resistance; GWAS; SNP; genomic selection; INFECTIOUS PANCREATIC NECROSIS; PISCIRICKETTSIA-SALMONIS; CATHEPSIN-L; MODEL; CONSERVATION; LOCI; REGRESSION; EXPRESSION; MANAGEMENT; SELECTION;
D O I
10.3389/fimmu.2024.1474746
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Enteritis caused by Vibrio is a highly die-off disease that severely impeded substantial production in seahorse aquaculture. In the present study, challenged with LD50 of concentration of Vibrio harveyi, a total of 161 of susceptible and 166 of resistant individuals were allocated into binary survival phenotypes, thus, to firstly investigate the genetic architecture by genome-wide association study (GWAS) analysis, as well as to evaluate the feasibility of genomic selection (GS) in enteritis disease resistance trait of the lined seahorse Hippocampus erectus. Results indicated that the heritability for resistance to Vibrio harveyi was estimated to be 0.10. And a set of 10 significant/suggestive SNPs in a multiple chromosomes localization were identified, explaining 7.76% to 13.28% of genetic variance. Associated 82 of candidate genes were clustered into signal transduction, cell proliferation, response of external stress, bacteria defence, and anti-inflammatory processes. Moreover, the potential performance of genomic selection (GS) in application in selective breeding for enteritis disease resistance seahorses was assessed by genomic prediction (GP). In general, the predictive accuracy of the genomic estimated breeding value (GEBV) of BayesC exceeded the rrBLUP, BayesA, RKHS, and SVM models while with no significant difference. And the GWAS-informative SNPs was significantly superior in efficience than random selected markers by comparison of predictive performance on different selection strategies of SNPs. Overall, the genetic basis of enteritis disease resistance trait in the lined seahorse is a polygenic genetic architecture. SNPs associated with the important genes of cathepsin L1-like previously reported with respect to disease resistance are consider as potential molecular markers of genetic breeding. Furthermore, GS approach is an appropriate, effective, and less-cost application in breeding enteritis disease-resistant seahorses.
引用
收藏
页数:14
相关论文
共 88 条
  • [1] Fast model-based estimation of ancestry in unrelated individuals
    Alexander, David H.
    Novembre, John
    Lange, Kenneth
    [J]. GENOME RESEARCH, 2009, 19 (09) : 1655 - 1664
  • [2] Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions
    Amini-Nik, Saeid
    Yousuf, Yusef
    Jeschke, Marc G.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2018, 123 : 135 - 154
  • [3] mir-182-5p regulates all three phases of inflammation, proliferation, and remodeling during cutaneous wound healing
    Amjadian, Sara
    Fatemi, Mohammad Javad
    Moradi, Sharif
    Hesaraki, Mahdi
    Mohammadi, Parvaneh
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2024, 316 (06)
  • [4] Arca-Ruibal B., 2005, ZooMed. Bull Br Vet Zool Soc, V5, P31
  • [5] Genomic selection for visceral white-nodules diseases resistance in large yellow croaker
    Bai, Yulin
    Wang, Jiaying
    Zhao, Ji
    Ke, Qiaozhen
    Qu, Ang
    Deng, Yacheng
    Zeng, Junjia
    Gong, Jie
    Chen, Jia
    Pan, Ying
    Chi, Hongshu
    Gong, Hui
    Zhou, Tao
    Xu, Peng
    [J]. AQUACULTURE, 2022, 559
  • [6] Phylogenetic characterization and in situ detection of bacterial communities associated with seahorses (Hippocampus guttulatus) in captivity
    Balcazar, Jose L.
    Lee, Natuschka M.
    Pintado, Jose
    Planas, Miquel
    [J]. SYSTEMATIC AND APPLIED MICROBIOLOGY, 2010, 33 (02) : 71 - 77
  • [7] A major quantitative trait locus affecting resistance to Tilapia lake virus in farmed Nile tilapia (Oreochromis niloticus)
    Barria, Agustin
    Trinh, Trong Quoc
    Mahmuddin, Mahirah
    Penaloza, Carolina
    Papadopoulou, Athina
    Gervais, Ophelie
    Chadag, V. Mohan
    Benzie, John A. H.
    Houston, Ross D.
    [J]. HEREDITY, 2021, 127 (3) : 334 - 343
  • [8] Single-Step Genome-Wide Association Study for Resistance to Piscirickettsia salmonis in Rainbow Trout (Oncorhynchus mykiss)
    Barria, Agustin
    Marin-Nahuelpi, Rodrigo
    Caceres, Pablo
    Lopez, Maria E.
    Bassini, Liane N.
    Lhorente, Jean P.
    Yanez, Jose M.
    [J]. G3-GENES GENOMES GENETICS, 2019, 9 (11): : 3833 - 3841
  • [9] Genomic Predictions and Genome-Wide Association Study of Resistance Against Piscirickettsia salmonis in Coho Salmon (Oncorhynchus kisutch) Using ddRAD Sequencing
    Barria, Agustin
    Christensen, Kris A.
    Yoshida, Grazyella M.
    Correa, Katharina
    Jedlicki, Ana
    Lhorente, Jean P.
    Davidson, William S.
    Yanez, Jose M.
    [J]. G3-GENES GENOMES GENETICS, 2018, 8 (04): : 1183 - 1194
  • [10] The infinitesimal model: Definition, derivation, and implications
    Barton, N. H.
    Etheridge, A. M.
    Veber, A.
    [J]. THEORETICAL POPULATION BIOLOGY, 2017, 118 : 50 - 73