HEPATIC DRUG-METABOLISM AND PHYSICAL-FITNESS

Physical fitness, as expressed by maximal O2 uptake (.ovrhdot.VO2 max), was measured in 14 subjects before and during physical education consisting of 4-8 h of daily physical training. Mean pulse rate during training was 115 bpm [beats/min]. After 3 mo. of physical training, .ovrhdot.VO2 max increased a mean 6% (range -5% to +23%). Corresponding mean increases in hepatic drug metabolism, as expressed by the metabolism of the model drugs antipyrine and aminopyrine, were 12% (range 12 to +59%) and 13% (range -21 to +47%). Changes in the 2 groups were still present 6 mo. after physical education. There was only a moderately close but nonetheless significant correlation (r = 0.7) between the extent of change in .ovrhdot.VO2 max and the corresponding relative change in antipyrine metabolism during the 3 mo. period of this investigation. The correlation between O2 uptake and aminopyrine metabolism (r = 0.6) was slightly less and was not significant. Improved physical fitness associated with enhanced drug metabolism may lead to changes in drug efficacy and drug toxicity that may be clinically important in the case of drugs with low therapeutic indices.