Phenolic compounds from the aerial parts of Artemisia vachanica Krasch. ex Poljakov

被引：0

作者：

Sukhrobov, Parviz ^{[1
,2
,3
]}

Li, Jun ^{[1
,2
]}

Tang, Dan ^{[1
]}

Numonov, Sodik ^{[1
,3
]}

Aisa, Haji Akber ^{[1
,2
,4
]}

机构：

[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Natl Acad Sci Tajikistan, Res Inst Chinese Tajik Innovat Ctr Nat Prod, Dushanbe 734063, Tajikistan

[4] Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Peoples R China

来源：

FITOTERAPIA | 2025年 / 182卷

关键词：

Artemisia vachanica; Isolation; Structural elucidation; Absolute configuration; Cytotoxicity; FLAVONOIDS; HORTENSIN; LIGNANS;

D O I：

10.1016/j.fitote.2025.106438

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pair of undescribed enantiomers of phenolic compound bearing a rare oxetane moiety, (+/-)-vachanin L [(+/-)-1], and an undescribed monoterpene, vachanin M (2), along with fifteen known compounds including a monoterpene (3), a diterpene (4), seven flavonoids (5-11) and six lignan analogs (12-17) were isolated from the aerial parts of Artemisia vachanica Krasch. ex Poljakov. Their structures were identified based on HR-ESI-MS and NMR spectroscopy techniques. Relative configuration of vachanin L (1) was established by 13C NMR calculations and DP4+ probability analysis, and absolute configurations of (+/-)-vachanin L [(+/-)-1] and vachanin M (2) were successfully confirmed by ECD calculations and X-ray diffraction analysis. Compound 4 exhibited significant cytotoxic activity against MCF7, HT29 and Hela cell lines with IC50 values of 23.20 mu M, 27.69 mu M and 36.93 mu M, respectively.

引用

页数：7

共 35 条

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