Epithelial membrane protein 1 in human cancer: a potential diagnostic biomarker and therapeutic target

被引：1

作者：

Xie, Yuxin ^{[1
]}

Wu, Feng ^{[1
]}

Chen, Zhe ^{[1
]}

Hou, Yu ^{[1
]}

机构：

[1] Chongqing Med Univ, Sch Basic Med Sci, Dept Radiol Med, Chongqing 400016, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 21-22期

关键词：

cancer; epithelial membrane protein 1; metastasis; prognosis; tumor biomarkers; CELL-PROLIFERATION; EMP1; PROMOTES; EXPRESSION; GENE; GROWTH; MIGRATION; METASTASIS; RESISTANCE; CARCINOMA; INVASION;

D O I：

10.1080/17520363.2024.2416887

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Epithelial membrane protein 1 (EMP1) is a member of the small hydrophobic membrane protein subfamily. EMP1 is aberrantly expressed in various tumor tissues and governs multiple cellular behaviors (e.g., proliferation, differentiation, and migration). The resultant regulation of the cancer pathway is responsible for the metastasis of cancer cells and determines the risk of malignant tumor progression. This review provides an updated overview of EMP1 as either an oncogene or a tumor suppressor contingent on the cancer type and summarizes its upstream regulators and downstream target genes. This systematic review summarizes our current understanding of the role of EMP1 in malignant tumor development, including critical functional mechanisms and implications for its potential use as the biomarker and therapeutic target.

引用

页码：995 / 1005

页数：11

共 98 条

[1] Loss of epithelial markers is an early event in oral dysplasia and is observed within the safety margin of dysplastic and T1 OSCC biopsies [J].

Abdalla, Zahra ;

Walsh, Tanya ;

Thakker, Nalin ;

Ward, Christopher M. .

PLOS ONE, 2017, 12 (12)

[2] The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis [J].

Amin, Mohammad Khusni B. Ahmat ;

Shimizu, Akio ;

Ogita, Hisakazu .

CANCERS, 2019, 11 (11)

[3] Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1 [J].

Amin, Mohammad Khusni B. Ahmat ;

Shimizu, Akio ;

Zankov, Dimitar P. ;

Sato, Akira ;

Kurita, Souichi ;

Ito, Masami ;

Maeda, Toshinaga ;

Yoshida, Tetsuya ;

Sakaue, Tomohisa ;

Higashiyama, Shigeki ;

Kawauchi, Akihiro ;

Ogita, Hisakazu .

ONCOGENE, 2018, 37 (40) :5416-5434

[4] EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion [J].

Aries, I. M. ;

Jerchel, I. S. ;

van den Dungen, R. E. S. R. ;

van den Berk, L. C. J. ;

Boer, J. M. ;

Horstmann, M. A. ;

Escherich, G. ;

Pieters, R. ;

den Boer, M. L. .

LEUKEMIA, 2014, 28 (09) :1828-1837

[5] Aberrant protein glycosylation: Implications on diagnosis and Immunotherapy [J].

Bangarh, Rashmi ;

Khatana, Chainika ;

Kaur, Simranjeet ;

Sharma, Anchita ;

Kaushal, Ankur ;

Siwal, Samarjeet Singh ;

Tuli, Hardeep Singh ;

Dhama, Kuldeep ;

Thakur, Vijay Kumar ;

Saini, Reena, V ;

Saini, Adesh K. .

BIOTECHNOLOGY ADVANCES, 2023, 66

[6] The epithelial membrane protein 1 is a novel tight junction protein of the blood-brain barrier [J].

Bangsow, Thorsten ;

Baumann, Ewa ;

Bangsow, Carmen ;

Jaeger, Martina H. ;

Pelzer, Bernhard ;

Gruhn, Petra ;

Wolf, Sabine ;

von Melchner, Harald ;

Stanimirovic, Danica B. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2008, 28 (06) :1249-1260

[7] CD44 as a potential diagnostic tumor marker [J].

Basakran, Nawwaf S. .

SAUDI MEDICAL JOURNAL, 2015, 36 (03) :273-279

[8] Targeting N-myristoylation for therapy of B-cell lymphomas [J].

Beauchamp, Erwan ;

Yap, Megan C. ;

Iyer, Aishwarya ;

Perinpanayagam, Maneka A. ;

Gamma, Jay M. ;

Vincent, Krista M. ;

Lakshmanan, Manikandan ;

Raju, Anandhkumar ;

Tergaonkar, Vinay ;

Tan, Soo Yong ;

Lim, Soon Thye ;

Dong, Wei-Feng ;

Postovit, Lynne M. ;

Read, Kevin D. ;

Gray, David W. ;

Wyatt, Paul G. ;

Mackey, John R. ;

Berthiaume, Luc G. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[9] Chromosomal mapping of TMP (EMP1), XMP (EMP2), and YMP (EMP3), genes encoding membrane proteins related to PMP22 [J].

Ben-Porath, I ;

Kozak, CA ;

Benvenisty, N .

GENOMICS, 1998, 49 (03) :443-447

[10] Silmitasertib plus gemcitabine and cisplatin first-line therapy in locally advanced/metastatic cholangiocarcinoma: A Phase 1b/2 study [J].

Borad, Mitesh J. ;

Bai, Li-Yuan ;

Richards, Donald ;

Mody, Kabir ;

Hubbard, Joleen ;

Rha, Sun Young ;

Soong, John ;

McCormick, Daniel ;

Tse, Emmett ;

O'Brien, Daniel ;

Bayat, Ahmad ;

Ahn, Daniel ;

Davis, S. Lindsey ;

Park, Joon Oh ;

Oh, Do-Youn .

HEPATOLOGY, 2023, 77 (03) :760-773

← 1 2 3 4 5 6 7 8 9 10 →