Bionic cell wall models: Utilizing TEMPO-oxidized cellulose nanofibers for fucoxanthin delivery systems

被引:0
作者
Tian, Fang [1 ,2 ]
Xu, Shuyi [1 ,2 ]
Gan, Miaoyu [2 ]
Chen, Baihui [1 ,2 ]
Luan, Qian [2 ,3 ]
Cai, Luyun [2 ,3 ]
机构
[1] Zhejiang Ocean Univ, Sch Food & Pharm, Key Lab Hlth Risk Factors Seafood Zhejiang Prov, Zhoushan 316022, Peoples R China
[2] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Ningbo Innovat Ctr, Ningbo 315100, Peoples R China
[3] NingboTech Univ, Sch Chem & Biol Engn, Ningbo 315100, Peoples R China
关键词
Fucoxanthin; TEMPO-oxidized cellulose nanofiber; Liposomes; Stability; LOADED LIPOSOMES; STABILITY; RELEASE; FOOD; OIL;
D O I
10.1016/j.carbpol.2024.122850
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Fucoxanthin (FX) has various excellent biological properties but suffers from poor bioavailability. In this work, we build a bionic cell wall model using TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy)-oxidized cellulose. The bionic cell wall enhances the environmental stability of the liposomes and serves as a pH-responsive mechanism. The coating processes protect the structure of liposomes and fucoxanthin under the acidic conditions of the stomach. The bionic cell wall disperses and releases the fucoxanthin in simulated intestinal fluid (SIF). Overall, the protective and release capabilities highlight the potential of cellulose in a bionic cell wall model and provide diversity for the structural design of carriers for delivering functional bioactive components.
引用
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页数:9
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