Prognostic Relevance of Immunophenotyping in Adult Patients with Acute Leukemia in Turkey: a Single-Center Experience

被引：0
作者：
Demirelce, Ozlem [1 ]
Orhan, Bagnu [1 ]
Sonmez, Derya [1 ]
Topac, Fatma H. [1 ]
Turk, Reyhan I. [1 ]
Altindal, Sermin [2 ]
Inal, Berrin B. [1 ]
机构：
[1] Univ Hlth Sci, Istanbul Training & Res Hosp, Dept Med Biochem, Abdurrahman Nafiz Gurman Caddesi, Faith, Istanbul, Turkiye
[2] Univ Hlth Sci, Istanbul Training & Res Hosp, Dept Hematol, Istanbul, Turkiye
来源：
CLINICAL LABORATORY | 2024年 / 70卷 / 10期
关键词：
Flow Cytometry; immunophenotyping; akut leukemias; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; EXPRESSION; MARKERS; SURFACE; COEXPRESSION; KARYOTYPE; ANTIGENS; DISEASE; BLASTS;
D O I：
10.7754/Clin.Lab.2024.240529
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: In acute leukemia, many associations have been identified between prognosis and some factors, such as individual antigen expression, cytogenetics, gender, age, high leukocyte level (WBC), platelet count (PLT), and lactate dehydrogenase (LDH), but few are consistent. In this study, we aimed to investigate the cell surface markers and other clinical pathological features for prognosis determination in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients in our population. Methods: This cross-sectional study was performed from January 2017 to December 2023 in & Idot;stanbul Training and Research Hospital and included 113 patients (86 AML and 27 ALL) newly diagnosed with AML (non-APL) and ALL. The following tests were fulfilled for the included patients: complete blood count (CBC), LDH, and flow cytometric analysis using a blood sample or bone marrow aspirate. The effects of surface markers, gender, age, WBC, PLT, and LDH on 24-month survival were evaluated retrospectively. Results: Among the investigated parameters, lack of CD13 expression and positive CD10, cTdT expressions were associated with poor prognosis in AML patients (p = 0.01, p = 0.04, and p = 0.04, respectively). We have found no association between the surface markers and other parameters with prognosis in ALL patients. Age > 65 years was associated with poor prognosis in both AML and ALL patients (p < 0.001). Conclusions: CD10, cTdT positivity, and CD13 negativity may predict poor prognosis for AML and can be considered as prognostic biomarkers for AML patients.
引用
收藏
页码：1966 / 1972
页数：7
相关论文
共 39 条
  • [1] Camos M, Colomer D., Molecular biology in acute leukemia, Clin Transl Oncol, 8, 8, pp. 550-559, (2006)
  • [2] Padilha SL, Souza EJ, Matos MC, Domino NR., Acute myeloid leukemia: survival analysis of patients at a university hospital of Paraná, Rev Bras Hematol Hemoter, 37, 1, pp. 21-27, (2015)
  • [3] Grimwade D., The changing paradigm of prognostic factors in acute myeloid leukemia, Best Pract Res Clin Haematol, 25, 4, pp. 419-425, (2012)
  • [4] Sharma RK, Purohit A, Somasundaram V, Et al., Aberrant myeloid antigen co-expression is correlated with high percentages of CD34-positive cells among blasts of acute lymphoblastic leukemia patients: an Indian tertiary care center perspective, Blood Res, 49, 4, pp. 241-245, (2014)
  • [5] Shao B, Gao Y-R, Wang C, Et al., Prognostic factor analysis of 77 old patients with acute myelogenous leukemia, Ai Zheng, 25, 8, pp. 1007-1012, (2006)
  • [6] Lauria F, Raspadori D, Ventura MA, Et al., The presence of lymphoid-associated antigens in adult acute myeloid leukemia is devoid of prognostic relevance, Stem Cells, 13, 4, pp. 428-434, (1995)
  • [7] de Nully Brown P, Jurlander J, Pedersen-Bjergaard J, Victor MA, Geisler CH., The prognostic significance of chromosomal analysis and immunophenotyping in 117 patients with de novo acute myeloid leukemia, Leuk Res, 21, 10, pp. 985-995, (1997)
  • [8] Ciolli S, Leoni F, Caporale R, Pascarella A, Salti F, Rossi-Ferrini P., CD34 expression fails to predict the outcome in adult acute myeloid leukemia, Haematologica, 78, 3, pp. 151-155, (1993)
  • [9] Pinheiro LHS, Trindade LD, Costa FO, Et al., Aberrant Phenotypes in Acute Myeloid Leukemia and Its Relationship with Prognosis and Survival: A Systematic Review and Meta-Analysis, Int J Hematol Oncol Stem Cell Res, 14, 4, pp. 274-288, (2020)
  • [10] Fang F, Zhu P, Zhang Y, Et al., Clinical Features and Prognosis of 227 cases of Acute Myeloid Leukemia with Cross-lineage Antigen Expression, Zhongguo Shi Yan Xue Ye Xue Za Zhi, 24, 4, pp. 990-997, (2016)
1234