Photocatalyst-Free Transformation of C(sp3)-H Bonds to Oxime Ethers via Photoinduced Hydrogen Atom Transfer

被引：0

作者：

Zhao, Yu-Lian ^{[1
,2
]}

Min, Xuehong ^{[3
]}

Li, Lijing ^{[1
,2
]}

Han, Xiao-Le ^{[1
,2
]}

Wei, Yi ^{[1
,2
]}

Hu, Xiao-Qiang ^{[1
,2
]}

机构：

[1] South Cent Minzu Univ, Sch Chem & Mat Sci, Key Lab Catalysis & Energy Mat Chem, Minist Educ, Wuhan 430074, Peoples R China

[2] South Cent Minzu Univ, Sch Chem & Mat Sci, Hubei Key Lab Catalysis & Mat Sci, Wuhan 430074, Peoples R China

[3] Wuhan Business Univ, Hubei Prov Engn Res Ctr Racing Horse Detect & Appl, Equine Sci Res & Horse Doping Control Lab, Wuhan 430056, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 43期

基金：

中国国家自然科学基金;

关键词：

FUNCTIONAL-GROUP; SINGLET OXYGEN; ACTIVATION; AZIDE;

D O I：

10.1021/acs.orglett.4c03653

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, a direct transformation of aliphatic C-H bonds to oxime ethers has been developed via light-promoted hydrogen atom transfer (HAT) in the absence of a photocatalyst. Singlet oxygen and chlorine radical are complementary C(sp(3))-H bond cleaving agents in this reaction, enabling the extraction of hydrogen atoms from a diverse range of compounds, like cycloalkanes, ethers, amines, amides, and cyclic sulfides. This method excels in transforming common aliphatic C-H bonds into valuable oxime ethers featuring abundant chemical feedstocks, good functional group tolerance, and catalyst free conditions.

引用

页码：9383 / 9388

页数：6

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