Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine☆

被引：3

作者：

Huang, Sai ^{[1
,2
]}

Chen, Peng ^{[1
,3
]}

Wang, Lu ^{[4
]}

Xu, Lingmin ^{[4
]}

Wang, Nan ^{[3
,4
]}

Li, Fei ^{[4
]}

Dou, Liping ^{[1
]}

Liu, Daihong ^{[1
,2
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Dept Hematol, Senior Dept Hematol, Med Ctr 5, 8th Dongdajie, Beijing 100039, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China

[3] Chinese PLA Med Sch, Beijing 100853, Peoples R China

[4] Peoples Liberat Army Gen Hosp, Dept Hematol, Med Ctr 1, Beijing 100853, Peoples R China

来源：

CANCER PATHOGENESIS AND THERAPY | 2024年 / 2卷 / 02期

基金：

国家重点研发计划; 北京市自然科学基金; 中国国家自然科学基金;

关键词：

Acute myeloid leukemia; Next-generation sequencing; Prognosis; DNA methyltransferase; Chemotherapy; CLONAL HEMATOPOIESIS; DOSE CYTARABINE; ALLELIC RATIO; COMBINATION; IMPACT; AZACITIDINE; ACLARUBICIN; MUTATIONS; PROGNOSIS; AML;

D O I：

10.1016/j.cpt.2023.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is associated with several biomarkers. Decitabine, a deoxyribonucleic acid (DNA) methyltransferase (DNMT) inhibitor, combined with cytarabine, aclarubicin hydrochloride, and granulocyte colony-stimulating factor (DCAG), has been used in patients newly diagnosed with AML. This regimen has been especially used in older and fragile patients who are immunocompromised or have co-morbidities, as well as those with specific gene mutations. However, the integration of molecular risk stratification and treatment guidance for the DCAG regimen has not been well defined. Therefore, this study aimed to investigate the genetic mutations associated with AML and establish appropriate treatment strategies for patients newly diagnosed with AML. Methods: This study analyzed the clinical data and genetic mutations based on next-generation sequencing (NGS) in 124 newly diagnosed patients with AML who received the DCAG regimen at the People's Liberation Army (PLA) General Hospital from January 2008 to August 2020. Factors associated with the cumulative incidence of relapse (CIR) and leukemia-free survival (LFS) in patients newly diagnosed with AML were analyzed.

引用

页码：112 / 120

页数：9

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