Association and Comparison of Systemic Inflammation Indicators and Myocardial Injury After Noncardiac Surgery in Older Patients

被引：0
作者：
Meng, Bingbing [1 ,2 ]
Zhang, Kai [1 ,2 ]
Liu, Chang [2 ,3 ]
Yao, Siyi [1 ,2 ]
Li, Zhao [1 ,2 ]
Lou, Jingsheng [1 ,2 ]
Fu, Qiang [1 ,2 ]
Liu, Yanhong [1 ,2 ]
Cao, Jiangbei [1 ,2 ]
Mi, Weidong [1 ,2 ,4 ]
Li, Hao [1 ,2 ,4 ]
机构：
[1] Chinese Peoples Liberat Army PLA, Med Sch, Beijing, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp PLAGH, Med Ctr 1, Dept Anesthesiol, 28th Fuxing Rd, Beijing 100853, Peoples R China
[3] Nankai Univ, Tianjin, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China
来源：
JOURNAL OF INFLAMMATION RESEARCH | 2025年 / 18卷
关键词：
neutrophil-to-lymphocyte ratio; NLR; platelet-to-lymphocyte ratio; PLR; systemic; immune; inflammation index; SII; myocardial injury after noncardiac surgery; MINS; ADVANCED-AGE PATIENTS; CARDIOVASCULAR-DISEASES; LYMPHOCYTE RATIO; COHORT; INDEX; NEUTROPHIL; MORTALITY; ADULTS; RISK;
D O I：
10.2147/JIR.S500795
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objective: To identify the association between preoperative inflammatory state and myocardial injury after noncardiac surgery (MINS) in older patients using systemic inflammation indicators neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) and to compare their clinical predictive values. Methods: This study included patients aged >= 65 years who underwent noncardiac surgery between January 2017 and August 2019. The relationship between preoperative inflammatory state and MINS was investigated using univariate and multivariate logistic regression analyses. The predictive values of NLR, PLR, and SII were determined by receiver operating characteristic (ROC) curve analysis. Based on the basic model we constructed, the predictive values were compared through separately adding NLR, PLR and SII. Results: Among 12464 patients, 965 (7.74%) developed MINS. The optimal cut-off values of NLR, PLR, and SII were 597x109, 2.59, and 923. Univariate and multivariate analyses show that preoperative inflammatory state is associated with MINS. In the multivariate analysis, the OR values for NLR, PLR, and SII were (OR: 1.61, 95% CI: 1.36-1.89, p<0.001), (OR: 1.28, 95% CI: 1.07-1.52, p=0.006), and (OR: 1.43, 95% CI: 1.20-1.70, p<0.001). ROC curve analysis indicated that NLR was more predictive of MINS (area under the curve [AUC]: 0.671, 95% CI: 0.652-0.689) than PLR (AUC: 0.635, 95% CI: 0.616-0.655) and SII (AUC: 0.648, 95% CI: 0.628-0.667). The addition of the NLR to a basic prediction model improved its predictive ability to a greater extent than the addition of PLR and SII. Conclusion: Higher preoperative inflammation levels are associated with an increased risk of MINS. The NLR, PLR, and SII are independent risk factors for MINS and NLR demonstrated better predictive value than that of PLR and SII.
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页码：3499 / 3510
页数：12
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