Glucose metrics and device satisfaction in adults with type 1 diabetes using different treatment modalities: a multicenter, real-world observational study

被引：0

作者：

Di Molfetta, S. ^{[1
]}

Rossi, A. ^{[2
,3
]}

Gesuita, R. ^{[4
]}

Faragalli, A. ^{[4
]}

Cutruzzola, A. ^{[5
]}

Irace, C. ^{[6
]}

Minuto, N. ^{[7
]}

Pitocco, D. ^{[8
]}

Cardella, F. ^{[9
]}

Arnaldi, C. ^{[10
]}

Frongia, A. ^{[11
]}

Mozzillo, E. ^{[12
]}

Predieri, B. ^{[13
]}

Fiorina, P. ^{[14
,15
,16
,17
]}

Giorgino, F. ^{[1
]}

Cherubini, V. ^{[18
]}

机构：

[1] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Sect Internal Med Endocrinol Androl & Metab Dis, I-70124 Bari, Italy

[2] IRCCS Osped Galeazzi St Ambrogio, I-20157 Milan, Italy

[3] Univ Milan, Dept Biomed & Clin Sci, I-20122 Milan, Italy

[4] Polytech Univ Marche, Ctr Epidemiol Biostat & Med Informat Technol, I-60020 Ancona, Italy

[5] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med, I-88100 Catanzaro, Italy

[6] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy

[7] IRCCS Ist Giannina Gaslini, Dept Pediat, I-16147 Genoa, Italy

[8] Fdn Policlin Univ Agostino Gemelli, Diabet Care Unit, UOSD Diabetol, IRCCS, I-00168 Rome, Italy

[9] Univ Palermo, Dept Pediat, I-90133 Palermo, Italy

[10] UOS Diabetol Pediat ASL Viterbo, I-01100 Viterbo, Italy

[11] Osped Brotzu, Diabet Unit, I-09134 Cagliari, Italy

[12] Federico II Univ Naples, Reg Ctr Pediat Diabet, Dept Translat Med Sci, Sect Pediat, Naples, Italy

[13] Univ Modena & Reggio Emilia, Dept Med & Surg Sci Mother, Children & Adults Pediat Unit, I-41124 Modena, Italy

[14] ASST Fatebenefratelli Sacco, Div Endocrinol, I-20121 Milan, Italy

[15] Univ Milan, Dept Biomed & Clin Sci L Sacco, I-20122 Milan, Italy

[16] Int Ctr T1D Pediat Clin Res Ctr Romeo & Enrica Inv, I-20157 Milan, Italy

[17] Harvard Med Sch, Boston Childrens Hosp, Nephrol Div, Boston, MA USA

[18] Salesi Hosp, Dept Womens & Childrens Hlth, I-60123 Ancona, Italy

来源：

ACTA DIABETOLOGICA | 2025年 / 62卷 / 04期

关键词：

Type; 1; diabetes; Adults; Treatment; Continuous subcutaneous insulin infusion; Hybrid closed loop; Time in range; Device satisfaction; GLYCEMIC CONTROL; HYPOGLYCEMIA; MANAGEMENT; ADOLESCENTS; TECHNOLOGY; REDUCTION;

D O I：

10.1007/s00592-024-02381-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To evaluate glucose metrics, device satisfaction and diabetes impact in adults with type 1 diabetes using different treatment modalities in a real-life setting in Italy. Methods: This was a multicentre, nationwide, cross-sectional study. Candidates were consecutively evaluated for eligibility during their routine medical visit at the diabetes centre. Researchers collected comprehensive demographic, socioeconomic, anamnestic and clinical data, and administered the Diabetes Impact and Device Satisfaction scale. Results: From 2021 to 2022, a total of 428 subjects, 45% males, with a median age of 32 years (IQR 23-47) were recruited in 11 participating centres from all over Italy. No differences in age, physical activity, and diabetes impact were found for the different treatment modalities. HCL/AHCL and SAP groups reported higher device satisfaction vs. MDI + SMBG and MDI + CGM (p < 0.001). Subjects treated with HCL/AHCL exhibited significantly higher TIR and significantly lower time spent in hypoglycemia level 1, time spent in hyperglycemia, CV and GMI compared to MDI + CGM, and significantly higher TIR and significantly lower time spent in hypoglycemia level 2, time spent in hyperglycemia, and CV compared to SAP. Significant reduction in hypoglycemia level 2 was also found with PLGM compared to SAP. High education attainment was associated with optimal metabolic control. Conclusion: Real-life use of advanced technologies for type 1 diabetes is associated with improved glucose metrics and device satisfaction. Education level also contributes to success of treatment.

引用

页码：563 / 573

页数：11

共 40 条

[1] Reduction in Hypoglycemia With the Predictive Low-Glucose Management System: A Long-term Randomized Controlled Trial in Adolescents With Type 1 Diabetes [J].

Abraham, Mary B. ;

Nicholas, Jennifer A. ;

Smith, Grant J. ;

Fairchild, Janice M. ;

King, Bruce R. ;

Ambler, Geoffrey R. ;

Cameron, Fergus J. ;

Davis, Elizabeth A. ;

Jones, Timothy W. .

DIABETES CARE, 2018, 41 (02) :303-310

[2] Prevention of Insulin-Induced Hypoglycemia in Type 1 Diabetes with Predictive Low Glucose Management System [J].

Abraham, Mary B. ;

de Bock, Martin ;

Paramalingam, Nirubasini ;

O'Grady, Michael J. ;

Ly, Trang T. ;

George, Carly ;

Roy, Anirban ;

Spital, Glenn ;

Karula, Sophy ;

Heels, Kristine ;

Gebert, Rebecca ;

Fairchild, Jan M. ;

King, Bruce R. ;

Ambler, Geoffrey R. ;

Cameron, Fergus ;

Davis, Elizabeth A. ;

Jones, Timothy W. .

DIABETES TECHNOLOGY & THERAPEUTICS, 2016, 18 (07) :436-443

[3] Associations between physical activity, sedentary behavior, and glycemic control in a large cohort of adolescents with type 1 diabetes: the Hvidoere Study Group on Childhood Diabetes [J].

Aman, J. ;

Skinner, T. C. ;

de Beaufort, C. E. ;

Swift, P. G. F. ;

Aanstoot, H-J ;

Cameron, F. .

PEDIATRIC DIABETES, 2009, 10 (04) :234-239

[4] Flash glucose monitoring (FGM): A clinical review on glycaemic outcomes and impact on quality of life [J].

Ang, Eshen ;

Lee, Zong Xuan ;

Moore, Sacha ;

Nana, Melanie .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2020, 34 (06)

[5]

Aouadi R, 2011, J SPORT MED PHYS FIT, V51, P393

[6]

Associazione dei Medici Diabetologi (AMD) della Societa Italiana di Diabetologia (SID) e della Societa Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP), LIN GUID ASS MED DIA

[7] Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range [J].

Battelino, Tadej ;

Danne, Thomas ;

Bergenstal, Richard M. ;

Amiel, Stephanie A. ;

Beck, Roy ;

Biester, Torben ;

Bosi, Emanuele ;

Buckingham, Bruce A. ;

Cefalu, William T. ;

Close, Kelly L. ;

Cobelli, Claudio ;

Dassau, Eyal ;

DeVries, J. Hans ;

Donaghue, Kim C. ;

Dovc, Klemen ;

Doyle, Francis J. ;

Garg, Satish ;

Grunberger, George ;

Heller, Simon ;

Heinemann, Lutz ;

Hirsch, Irl B. ;

Hovorka, Roman ;

Jia, Weiping ;

Kordonouri, Olga ;

Kovatchev, Boris ;

Kowalski, Aaron ;

Laffel, Lori ;

Levine, Brian ;

Mayorov, Alexander ;

Mathieu, Chantal ;

Murphy, Helen R. ;

Nimri, Revital ;

Norgaard, Kirsten ;

Parkin, Christopher G. ;

Renard, Eric ;

Rodbard, David ;

Saboo, Banshi ;

Schatz, Desmond ;

Stoner, Keaton ;

Urakami, Tatsuiko ;

Weinzimer, Stuart A. ;

Phillip, Moshe .

DIABETES CARE, 2019, 42 (08) :1593-1603

[8] Real-world outcomes with different technology modalities in type 1 diabetes [J].

Beato-Vibora, Pilar, I ;

Gallego-Gamero, Fabiola ;

Ambrojo-Lopez, Ana .

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2021, 31 (06) :1845-1850

[9] Sensor-Augmented Pump Therapy for A1C Reduction (STAR 3) Study [J].

Bergenstal, Richard M. ;

Tamborlane, William V. ;

Ahmann, Andrew ;

Buse, John B. ;

Dailey, George ;

Davis, Stephen N. ;

Joyce, Carol ;

Perkins, Bruce A. ;

Welsh, John B. ;

Willi, Steven M. ;

Wood, Michael A. .

DIABETES CARE, 2011, 34 (11) :2403-2405

[10] The automated pancreas: A review of technologies and clinical practice [J].

Biester, Torben ;

Tauschmann, Martin ;

Chobot, Agata ;

Kordonouri, Olga ;

Danne, Thomas ;

Kapellen, Thomas ;

Dovc, Klemen .

DIABETES OBESITY & METABOLISM, 2022, 24 :43-57

← 1 2 3 4 →